論文 - 詳細
| RRC ID | 53354 |
|---|---|
| 著者 | Ujisawa T, Ohta A, Uda-Yagi M, Kuhara A. |
| タイトル | Diverse Regulation of Temperature Sensation by Trimeric G-Protein Signaling in Caenorhabditis elegans. |
| ジャーナル | PLoS One |
| Abstract |
Temperature sensation by the nervous system is essential for life and proliferation of animals. The molecular-physiological mechanisms underlying temperature signaling have not been fully elucidated. We show here that diverse regulatory machinery underlies temperature sensation through trimeric G-protein signaling in the nematode Caenorhabditis elegans. Molecular-genetic studies demonstrated that cold tolerance is regulated by additive functions of three Gα proteins in a temperature-sensing neuron, ASJ, which is also known to be a light-sensing neuron. Optical recording of calcium concentration in ASJ upon temperature-changes demonstrated that three Gα proteins act in different aspects of temperature signaling. Calcium concentration changes in ASJ upon temperature change were unexpectedly decreased in a mutant defective in phosphodiesterase, which is well known as a negative regulator of calcium increase. Together, these data demonstrate commonalities and differences in the molecular components concerned with light and temperature signaling in a single sensory neuron. |
| 巻・号 | 11(10) |
| ページ | e0165518 |
| 公開日 | 2016-1-1 |
| DOI | 10.1371/journal.pone.0165518 |
| PII | PONE-D-16-19856 |
| PMID | 27788246 |
| PMC | PMC5082853 |
| MeSH | Adaptation, Physiological Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology Calcium / metabolism Cold Temperature GTP-Binding Proteins / metabolism* Germ Cells Microscopy, Confocal Signal Transduction* Temperature* |
| IF | 2.74 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3098 |