論文 - 詳細
| RRC ID | 53360 |
|---|---|
| 著者 | Torpe N, Nørgaard S, Høye AM, Pocock R. |
| タイトル | Developmental Wiring of Specific Neurons Is Regulated by RET-1/Nogo-A in Caenorhabditis elegans. |
| ジャーナル | Genetics |
| Abstract |
Nogo-A is a membrane-bound protein that functions to inhibit neuronal migration, adhesion, and neurite outgrowth during development. In the mature nervous system, Nogo-A stabilizes neuronal wiring to inhibit neuronal plasticity and regeneration after injury. Here, we show that RET-1, the sole Nogo-A homolog in Caenorhabditis elegans, is required to control developmental wiring of a specific subset of neurons. In ret-1 deletion mutant animals, specific ventral nerve cord axons are misguided where they fail to respect the ventral midline boundary. We found that ret-1 is expressed in multiple neurons during development, and, through mosaic analysis, showed that ret-1 controls axon guidance in a cell-autonomous manner. Finally, as in mammals, ret-1 regulates ephrin expression, and dysregulation of the ephrin ligand VAB-2 is partially responsible for the ret-1 mutant axonal defects. Together, our data present a previously unidentified function for RET-1 in the nervous system of C. elegans. |
| 巻・号 | 205(1) |
| ページ | 295-302 |
| 公開日 | 2017-1-1 |
| DOI | 10.1534/genetics.115.185322 |
| PII | genetics.115.185322 |
| PMID | 27821431 |
| PMC | PMC5223509 |
| MeSH | Animals Axons / metabolism Axons / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Ephrins / metabolism Membrane Proteins / genetics Motor Neurons / cytology Motor Neurons / metabolism Motor Neurons / physiology Neurogenesis / genetics Neurons / cytology Neurons / metabolism Neurons / physiology* Nogo Proteins / biosynthesis Nogo Proteins / genetics Nogo Proteins / metabolism Nogo Proteins / physiology* |
| IF | 4.015 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm390 |