RRC ID 53363
著者 Abdu Y, Maniscalco C, Heddleston JM, Chew TL, Nance J.
タイトル Developmentally programmed germ cell remodelling by endodermal cell cannibalism.
ジャーナル Nat Cell Biol
Abstract Primordial germ cells (PGCs) in many species associate intimately with endodermal cells, but the significance of such interactions is largely unexplored. Here, we show that Caenorhabditis elegans PGCs form lobes that are removed and digested by endodermal cells, dramatically altering PGC size and mitochondrial content. We demonstrate that endodermal cells do not scavenge lobes PGCs shed, but rather, actively remove lobes from the cell body. CED-10 (Rac)-induced actin, DYN-1 (dynamin) and LST-4 (SNX9) transiently surround lobe necks and are required within endodermal cells for lobe scission, suggesting that scission occurs through a mechanism resembling vesicle endocytosis. These findings reveal an unexpected role for endoderm in altering the contents of embryonic PGCs, and define a form of developmentally programmed cell remodelling involving intercellular cannibalism. Active roles for engulfing cells have been proposed in several neuronal remodelling events, suggesting that intercellular cannibalism may be a more widespread method used to shape cells than previously thought.
巻・号 18(12)
ページ 1302-1310
公開日 2016-12-1
DOI 10.1038/ncb3439
PII ncb3439
PMID 27842058
PMC PMC5129868
MeSH Animals Caenorhabditis elegans / cytology Caenorhabditis elegans Proteins / metabolism Cellular Reprogramming* Cytophagocytosis* Dynamins / metabolism Endoderm / cytology* Germ Cells / cytology* Germ Cells / metabolism Mitochondria / metabolism
IF 20.042
引用数 18
リソース情報
線虫 tm597 tm2078