論文 - 詳細
| RRC ID | 53422 |
|---|---|
| 著者 | Díaz-Balzac CA, Lázaro-Peña MI, Ramos-Ortiz GA, Bülow HE. |
| タイトル | The Adhesion Molecule KAL-1/anosmin-1 Regulates Neurite Branching through a SAX-7/L1CAM-EGL-15/FGFR Receptor Complex. |
| ジャーナル | Cell Rep |
| Abstract |
Neurite branching is essential for correct assembly of neural circuits, yet it remains a poorly understood process. For example, the neural cell adhesion molecule KAL-1/anosmin-1, which is mutated in Kallmann syndrome, regulates neurite branching through mechanisms largely unknown. Here, we show that KAL-1/anosmin-1 mediates neurite branching as an autocrine co-factor with EGL-17/FGF through a receptor complex consisting of the conserved cell adhesion molecule SAX-7/L1CAM and the fibroblast growth factor receptor EGL-15/FGFR. This protein complex, which appears conserved in humans, requires the immunoglobulin (Ig) domains of SAX-7/L1CAM and the FN(III) domains of KAL-1/anosmin-1 for formation in vitro as well as function in vivo. The kinase domain of the EGL-15/FGFR is required for branching, and genetic evidence suggests that ras-mediated signaling downstream of EGL-15/FGFR is necessary to effect branching. Our studies establish a molecular pathway that regulates neurite branching during development of the nervous system. |
| 巻・号 | 11(9) |
| ページ | 1377-84 |
| 公開日 | 2015-6-9 |
| DOI | 10.1016/j.celrep.2015.04.057 |
| PII | S2211-1247(15)00474-X |
| PMID | 26004184 |
| PMC | PMC4464948 |
| MeSH | Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism* HEK293 Cells Humans Immunoprecipitation Nerve Tissue Proteins / metabolism* Neural Cell Adhesion Molecule L1 / metabolism Neural Cell Adhesion Molecules / metabolism Neurites / metabolism* Neurogenesis / physiology* Receptors, Fibroblast Growth Factor / metabolism Signal Transduction / physiology* |
| IF | 8.109 |
| 引用数 | 20 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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