RRC ID 53464
Author Reddy KC, Dunbar TL, Nargund AM, Haynes CM, Troemel ER.
Title The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
Journal Cell Rep
Abstract Pathogens attack host cells by deploying toxins that perturb core host processes. Recent findings from the nematode C. elegans and other metazoans indicate that surveillance or "effector-triggered" pathways monitor functioning of these core processes and mount protective responses when they are perturbed. Despite a growing number of examples of surveillance immunity, the signaling components remain poorly defined. Here, we show that CEBP-2, the C. elegans ortholog of mammalian CCAAT-enhancer-binding protein gamma, is a key player in surveillance immunity. We show that CEBP-2 acts together with the bZIP transcription factor ZIP-2 in the protective response to translational block by P. aeruginosa Exotoxin A as well as perturbations of other processes. CEBP-2 serves to limit pathogen burden, promote survival upon P. aeruginosa infection, and also promote survival upon Exotoxin A exposure. These findings may have broad implications for the mechanisms by which animals sense pathogenic attack and mount protective responses.
Volume 14(7)
Pages 1581-1589
Published 2016-2-23
DOI 10.1016/j.celrep.2016.01.055
PII S2211-1247(16)30033-X
PMID 26876169
PMC PMC4767654
MeSH ADP Ribose Transferases / biosynthesis ADP Ribose Transferases / immunology Animals Bacterial Toxins / biosynthesis Bacterial Toxins / immunology CCAAT-Enhancer-Binding Proteins / antagonists & inhibitors CCAAT-Enhancer-Binding Proteins / genetics CCAAT-Enhancer-Binding Proteins / immunology* Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / immunology* Death-Associated Protein Kinases / antagonists & inhibitors Death-Associated Protein Kinases / genetics Death-Associated Protein Kinases / immunology* Exotoxins / biosynthesis Exotoxins / immunology Gene Expression Regulation / immunology Host-Pathogen Interactions* Immunity, Innate Immunologic Surveillance* Pseudomonas aeruginosa / growth & development* Pseudomonas aeruginosa / immunology RNA, Small Interfering / genetics RNA, Small Interfering / metabolism Signal Transduction Survival Rate Virulence Factors / biosynthesis Virulence Factors / immunology
IF 8.109
Times Cited 15
C.elegans tm5421 tm4248