論文 - 詳細
| RRC ID | 53477 |
|---|---|
| 著者 | Kinet MJ, Malin JA, Abraham MC, Blum ES, Silverman MR, Lu Y, Shaham S. |
| タイトル | HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans. |
| ジャーナル | Elife |
| Abstract |
Apoptosis is a prominent metazoan cell death form. Yet, mutations in apoptosis regulators cause only minor defects in vertebrate development, suggesting that another developmental cell death mechanism exists. While some non-apoptotic programs have been molecularly characterized, none appear to control developmental cell culling. Linker-cell-type death (LCD) is a morphologically conserved non-apoptotic cell death process operating in Caenorhabditis elegans and vertebrate development, and is therefore a compelling candidate process complementing apoptosis. However, the details of LCD execution are not known. Here we delineate a molecular-genetic pathway governing LCD in C. elegans. Redundant activities of antagonistic Wnt signals, a temporal control pathway, and mitogen-activated protein kinase kinase signaling control heat shock factor 1 (HSF-1), a conserved stress-activated transcription factor. Rather than protecting cells, HSF-1 promotes their demise by activating components of the ubiquitin proteasome system, including the E2 ligase LET-70/UBE2D2 functioning with E3 components CUL-3, RBX-1, BTBD-2, and SIAH-1. Our studies uncover design similarities between LCD and developmental apoptosis, and provide testable predictions for analyzing LCD in vertebrates. |
| 巻・号 | 5 |
| 公開日 | 2016-3-8 |
| DOI | 10.7554/eLife.12821 |
| PII | e12821 |
| PMID | 26952214 |
| PMC | PMC4821803 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism* Cell Death* Gene Expression Regulation, Developmental Proteasome Endopeptidase Complex / metabolism* Signal Transduction Transcription Factors / metabolism* Ubiquitin / metabolism* |
| IF | 7.08 |
| 引用数 | 12 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2777 tm1968 |