論文 - 詳細
| RRC ID | 53484 |
|---|---|
| 著者 | Cherra SJ 3rd, Jin Y. |
| タイトル | A Two-Immunoglobulin-Domain Transmembrane Protein Mediates an Epidermal-Neuronal Interaction to Maintain Synapse Density. |
| ジャーナル | Neuron |
| Abstract |
Synaptic maintenance is essential for neural circuit function. In the C. elegans locomotor circuit, motor neurons are in direct contact with the epidermis. Here, we reveal a novel epidermal-neuronal interaction mediated by a two-immunoglobulin domain transmembrane protein, ZIG-10, that is necessary for maintaining cholinergic synapse density. ZIG-10 is localized at the cell surface of epidermis and cholinergic motor neurons, with high levels at areas adjacent to synapses. Loss of zig-10 increases the number of cholinergic excitatory synapses and exacerbates convulsion behavior in a seizure model. Mis-expression of zig-10 in GABAergic inhibitory neurons reduces GABAergic synapse number, dependent on the presence of ZIG-10 in the epidermis. Furthermore, ZIG-10 interacts with the tyrosine kinase SRC-2 to regulate the phagocytic activity of the epidermis to restrict cholinergic synapse number. Our studies demonstrate the highly specific roles of non-neuronal cells in modulating neural circuit function, through neuron-type-specific maintenance of synapse density. |
| 巻・号 | 89(2) |
| ページ | 325-36 |
| 公開日 | 2016-1-20 |
| DOI | 10.1016/j.neuron.2015.12.024 |
| PII | S0896-6273(15)01126-5 |
| PMID | 26777275 |
| PMC | PMC4871750 |
| MeSH | Amino Acid Sequence Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Epidermis / metabolism* HEK293 Cells Humans Immunoglobulins / genetics Immunoglobulins / metabolism* Molecular Sequence Data Neurons / metabolism* Synapses / metabolism* |
| IF | 14.403 |
| 引用数 | 16 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm6127 |