Reference - Detail
| RRC ID | 53497 |
|---|---|
| Author | Matsuura T, Urushihata T. |
| Title | Chronic nicotine exposure augments gustatory plasticity in Caenorhabditis elegans: involvement of dopamine signaling. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
The chemotaxis of wild-type NaCl-conditioned nematodes exposed to 100 mM NaCl, maintained on a growth medium containing 0.3 mM nicotine from first larva to young adult (YA) hermaphrodite, was significantly weaker than the chemotaxis of those maintained on a medium without nicotine. The result indicates that chronic nicotine exposure augments gustatory plasticity. The gustatory plasticity was also augmented when tph-1 mutants, with a defect in serotonin biosynthesis, were maintained on a medium containing nicotine until the YA stage. Chronic nicotine exposure did not augment gustatory plasticity in bas-1 mutants, which had defects in both serotonin and dopamine biosynthesis, and in cat-2 mutants, which had a defect in dopamine biosynthesis. However, augmentation of gustatory plasticity was observed when bas-1 and cat-2 mutants were maintained on a growth medium containing nicotine along with dopamine, suggesting that dopamine signaling is involved in the augmentation of gustatory plasticity due to chronic nicotine exposure. |
| Volume | 79(3) |
| Pages | 462-9 |
| Published | 2015-1-1 |
| DOI | 10.1080/09168451.2014.980220 |
| PMID | 25428810 |
| MeSH | Animals Caenorhabditis elegans* Dopamine / metabolism* Neuronal Plasticity / drug effects* Nicotine / adverse effects* Receptors, Nicotinic / metabolism Signal Transduction / drug effects* Taste Perception / drug effects* Taste Perception / physiology* Time Factors |
| IF | 1.516 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | |