論文 - 詳細
| RRC ID | 53510 |
|---|---|
| 著者 | Babu V, Schumacher B. |
| タイトル | A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. |
| ジャーナル | DNA Repair (Amst) |
| Abstract |
The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking DNA lesions, particularly UV-induced damage. Clinical symptoms of the two TC-NER-deficiency syndromes, Cockayne syndrome (CS) and UV-hypersensitivity syndrome (UVSS) are dissimilar and the underlying molecular mechanism causing this difference in disease pathology is not yet clearly understood. UV-stimulated scaffold protein A (UVSSA) has been identified recently as a new causal gene for UVSS. Here we describe a functional homolog of the human UVSSA gene in the nematode Caenorhabditis elegans, uvs-1 (UVSSA-like-1). Mutations in uvs-1 render the animals hypersensitive to UV-B irradiation and transcription-blocking lesion-inducing illudin-M, similar to mutations in TC-NER deficient mutants. Moreover, we demonstrate that TC-NER factors including UVS-1 are required for the survival of the adult animals after UV-treatment. |
| 巻・号 | 41 |
| ページ | 8-15 |
| 公開日 | 2016-5-1 |
| DOI | 10.1016/j.dnarep.2016.03.008 |
| PII | S1568-7864(15)30108-7 |
| PMID | 27043179 |
| PMC | PMC4886821 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology Caenorhabditis elegans / radiation effects* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics* DNA Repair / drug effects DNA Repair / genetics DNA Repair / radiation effects Humans Longevity / drug effects Longevity / genetics Longevity / radiation effects Mutation Oxidative Stress / drug effects Oxidative Stress / genetics Oxidative Stress / radiation effects Polycyclic Sesquiterpenes Sequence Homology, Nucleic Acid* Sesquiterpenes / pharmacology Transcription, Genetic / drug effects Transcription, Genetic / radiation effects Ultraviolet Rays / adverse effects* |
| IF | 3.339 |
| 引用数 | 3 |
| リソース情報 | |
| 線虫 | tm3886 tm6134 tm6311 |