論文 - 詳細
| RRC ID | 53512 |
|---|---|
| 著者 | Chen YC, Chen HJ, Tseng WC, Hsu JM, Huang TT, Chen CH, Pan CL. |
| タイトル | A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling. |
| ジャーナル | Dev Cell |
| Abstract |
Sensory perception, including thermosensation, shapes longevity in diverse organisms, but longevity-modulating signals from the sensory neurons are largely obscure. Here we show that CRH-1/CREB activation by CMK-1/CaMKI in the AFD thermosensory neuron is a key mechanism that maintains lifespan at warm temperatures in C. elegans. In response to temperature rise and crh-1 activation, the AFD neurons produce and secrete the FMRFamide neuropeptide FLP-6. Both CRH-1 and FLP-6 are necessary and sufficient for longevity at warm temperatures. Our data suggest that FLP-6 targets the AIY interneurons and engages DAF-9 sterol hormone signaling. Moreover, we show that FLP-6 signaling downregulates ins-7/insulin-like peptide and several insulin pathway genes, whose activity compromises lifespan. Our work illustrates how temperature experience is integrated by the thermosensory circuit to generate neuropeptide signals that remodel insulin and sterol hormone signaling and reveals a neuronal-endocrine circuit driven by thermosensation to promote temperature-specific longevity. |
| 巻・号 | 39(2) |
| ページ | 209-223 |
| 公開日 | 2016-10-24 |
| DOI | 10.1016/j.devcel.2016.08.021 |
| PII | S1534-5807(16)30596-2 |
| PMID | 27720609 |
| MeSH | Animals Body Temperature / physiology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Genes, Helminth Heat-Shock Response / genetics Hot Temperature Interneurons / metabolism Intestinal Mucosa / metabolism Longevity / physiology* Models, Biological Mutation / genetics Neuropeptides / genetics Neuropeptides / metabolism* Peptide Hormones / metabolism Sensory Receptor Cells / metabolism Signal Transduction* / genetics Transcription Factors / metabolism* Transcription, Genetic |
| IF | 10.092 |
| 引用数 | 19 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2869 tm1996 tm2001 tm2984 tm2001 |