Reference - Detail
| RRC ID | 53516 |
|---|---|
| Author | Desjardins D, Cacho-Valadez B, Liu JL, Wang Y, Yee C, Bernard K, Khaki A, Breton L, Hekimi S. |
| Title | Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. |
| Journal | Aging Cell |
| Abstract |
Reactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules that modulate aging. Recent observations that ROS can promote longevity have to be reconciled with the numerous claims about the benefits of antioxidants on lifespan. Here, three antioxidants [N-acetylcysteine (NAC), vitamin C, and resveratrol (RSV)] were tested on Caenorhabditis elegans mutants that alter drug uptake, mitochondrial function, and ROS metabolism. We observed that like pro-oxidants, antioxidants can both lengthen and shorten lifespan, dependent on concentration, genotypes, and conditions. The effects of antioxidants thus reveal an inverted U-shaped dose-response relationship between ROS levels and lifespan. In addition, we observed that RSV can act additively to both NAC and paraquat, to dramatically increase lifespan. This suggests that the effect of compounds that modulate ROS levels can be additive when their loci of action or mechanisms of action are sufficiently distinct. |
| Volume | 16(1) |
| Pages | 104-112 |
| Published | 2017-2-1 |
| DOI | 10.1111/acel.12528 |
| PMID | 27683245 |
| PMC | PMC5242296 |
| MeSH | Acetylcysteine / pharmacology Aging / drug effects Aging / physiology* Animals Antioxidants / pharmacology* Ascorbic Acid / pharmacology Caenorhabditis elegans / drug effects Caenorhabditis elegans / physiology* Longevity / drug effects Mitochondria / drug effects Mitochondria / metabolism Models, Biological Mutation / genetics Oxidative Stress / drug effects Paraquat / pharmacology Reactive Oxygen Species / metabolism* Resveratrol Stilbenes / pharmacology Superoxide Dismutase / metabolism |
| IF | 7.346 |
| Times Cited | 26 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 14 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm783 tm760 tm1246 |