論文 - 詳細
| RRC ID | 53535 |
|---|---|
| 著者 | Singhvi A, Liu B, Friedman CJ, Fong J, Lu Y, Huang XY, Shaham S. |
| タイトル | A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC. |
| ジャーナル | Cell |
| Abstract |
Neurons receive input from the outside world or from other neurons through neuronal receptive endings (NREs). Glia envelop NREs to create specialized microenvironments; however, glial functions at these sites are poorly understood. Here, we report a molecular mechanism by which glia control NRE shape and associated animal behavior. The C. elegans AMsh glial cell ensheathes the NREs of 12 neurons, including the thermosensory neuron AFD. KCC-3, a K/Cl transporter, localizes specifically to a glial microdomain surrounding AFD receptive ending microvilli, where it regulates K(+) and Cl(-) levels. We find that Cl(-) ions function as direct inhibitors of an NRE-localized receptor-guanylyl-cyclase, GCY-8, which synthesizes cyclic guanosine monophosphate (cGMP). High cGMP mediates the effects of glial KCC-3 on AFD shape by antagonizing the actin regulator WSP-1/NWASP. Components of this pathway are broadly expressed throughout the nervous system, suggesting that ionic regulation of the NRE microenvironment may be a conserved mechanism by which glia control neuron shape and function. |
| 巻・号 | 165(4) |
| ページ | 936-48 |
| 公開日 | 2016-5-5 |
| DOI | 10.1016/j.cell.2016.03.026 |
| PII | S0092-8674(16)30322-1 |
| PMID | 27062922 |
| PMC | PMC4860081 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / metabolism Cyclic GMP / metabolism Guanylate Cyclase / chemistry Guanylate Cyclase / metabolism K Cl- Cotransporters Neuroglia / metabolism* Potassium / metabolism Protein Domains Sensory Receptor Cells / metabolism* Symporters / chemistry Symporters / genetics Symporters / metabolism* Thermosensing |
| IF | 38.637 |
| 引用数 | 27 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3649 tm3098 tm949 |