RRC ID 53924
Author Ren L, Mo D, Li Y, Liu T, Yin H, Jiang N, Zhang J.
Title A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila.
Journal PLoS One
Abstract Notch signaling is conserved in most multicellular organisms and plays critical roles during animal development. The core components and major signal transduction mechanism of Notch signaling have been extensively studied. However, our understanding of how Notch signaling activity is regulated in diverse developmental processes still remains incomplete. Here, we report a genetic mosaic screen in Drosophila melanogaster that leads to identification of Notch signali ng modulators during wing development. We discovered a group of genes required for the formation of the fly wing margin, a developmental process that is strictly dependent on the balanced Notch signaling activity. These genes encode transcription factors, protein phosphatases, vacuolar ATPases and factors required for RNA transport, stability, and translation. Our data support the view that Notch signaling is controlled through a wide range of molecular processes. These results also provide foundations for further study by showing that Me31B and Wdr62 function as two novel modulators of Notch signaling activity.
Volume 13(9)
Pages e0203781
Published 2018-9-20
DOI 10.1371/journal.pone.0203781
PII PONE-D-18-04097
PMID 30235233
PMC PMC6147428
MeSH Animals DEAD-box RNA Helicases / genetics DEAD-box RNA Helicases / metabolism DEAD-box RNA Helicases / physiology* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Regulation Genetic Testing / methods Nerve Tissue Proteins / genetics* Nerve Tissue Proteins / metabolism Nerve Tissue Proteins / physiology* Receptors, Notch / genetics Receptors, Notch / metabolism* Signal Transduction / genetics
IF 2.74
Times Cited 2
Drosophila 7337R-1 DGRC#150096 DGRC#150067