| RRC ID |
53924
|
| 著者 |
Ren L, Mo D, Li Y, Liu T, Yin H, Jiang N, Zhang J.
|
| タイトル |
A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila.
|
| ジャーナル |
PLoS One
|
| Abstract |
Notch signaling is conserved in most multicellular organisms and plays critical roles during animal development. The core components and major signal transduction mechanism of Notch signaling have been extensively studied. However, our understanding of how Notch signaling activity is regulated in diverse developmental processes still remains incomplete. Here, we report a genetic mosaic screen in Drosophila melanogaster that leads to identification of Notch signali ng modulators during wing development. We discovered a group of genes required for the formation of the fly wing margin, a developmental process that is strictly dependent on the balanced Notch signaling activity. These genes encode transcription factors, protein phosphatases, vacuolar ATPases and factors required for RNA transport, stability, and translation. Our data support the view that Notch signaling is controlled through a wide range of molecular processes. These results also provide foundations for further study by showing that Me31B and Wdr62 function as two novel modulators of Notch signaling activity.
|
| 巻・号 |
13(9)
|
| ページ |
e0203781
|
| 公開日 |
2018-9-20
|
| DOI |
10.1371/journal.pone.0203781
|
| PII |
PONE-D-18-04097
|
| PMID |
30235233
|
| PMC |
PMC6147428
|
| MeSH |
Animals
DEAD-box RNA Helicases / genetics
DEAD-box RNA Helicases / metabolism
DEAD-box RNA Helicases / physiology*
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism
Drosophila Proteins / physiology*
Drosophila melanogaster / genetics*
Drosophila melanogaster / metabolism
Gene Expression Regulation
Genetic Testing / methods
Nerve Tissue Proteins / genetics*
Nerve Tissue Proteins / metabolism
Nerve Tissue Proteins / physiology*
Receptors, Notch / genetics
Receptors, Notch / metabolism*
Signal Transduction / genetics
|
| IF |
2.74
|
| 引用数 |
2
|
| リソース情報 |
| ショウジョウバエ |
7337R-1
DGRC#150096
DGRC#150067 |
