RRC ID 53934
Author Noma Y, Sideras P, Naito T, Bergstedt-Lindquist S, Azuma C, Severinson E, Tanabe T, Kinashi T, Matsuda F, Yaoita Y.
Title Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter.
Journal Nature
Abstract Complementary DNA encoding the IgG1 induction factor, the first lymphokine directed to B lymphocytes, from a murine T-cell line has been cloned using a new strategy. The putative primary amino-acid sequence was deduced from the nucleotide sequence determined. The lymphokine synthesized by the direction of this cloned cDNA has many other functions, such as production of B-cell growth factor-1 and induction of Ia on B cells.
Volume 319(6055)
Pages 640-6
Published 1986-2-20
DOI 10.1038/319640a0
PMID 3005865
MeSH Amino Acid Sequence Animals B-Lymphocytes / immunology* Base Sequence Chromosome Mapping Cloning, Molecular DNA / genetics DNA Restriction Enzymes Genetic Vectors Growth Substances / genetics* Histocompatibility Antigens Class II / analysis Immunoglobulin G / biosynthesis Interleukin-4 Lymphokines / genetics* Mice Promoter Regions, Genetic Protein Biosynthesis RNA, Messenger / genetics T-Lymphocytes / physiology* Xenopus laevis
IF 42.779
Times Cited 547
DNA material pSP6K. m. IL-4-374 (RDB01173)