論文 - 詳細
| RRC ID | 53936 |
|---|---|
| 著者 | Harvald EB, Sprenger RR, Dall KB, Ejsing CS, Nielsen R, Mandrup S, Murillo AB, Larance M, Gartner A, Lamond AI, Færgeman NJ. |
| タイトル | Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans. |
| ジャーナル | Cell Syst |
| Abstract |
Starvation causes comprehensive metabolic changes, which are still not fully understood. Here, we used quantitative proteomics and RNA sequencing to examine the temporal starvation responses in wild-type Caenorhabditis elegans and animals lacking the transcription factor HLH-30. Our findings show that starvation alters the abundance of hundreds of proteins and mRNAs in a temporal manner, many of which are involved in central metabolic pathways, including lipoprotein metabolism. We demonstrate that premature death of hlh-30 animals under starvation can be prevented by knockdown of either vit-1 or vit-5, encoding two different lipoproteins. We further show that the size and number of intestinal lipid droplets under starvation are altered in hlh-30 animals, which can be rescued by knockdown of vit-1. Taken together, this indicates that survival of hlh-30 animals under starvation is closely linked to regulation of intestinal lipid stores. We provide the most detailed poly-omic analysis of starvation responses to date, which serves as a resource for further mechanistic studies of starvation. |
| 巻・号 | 5(1) |
| ページ | 38-52.e4 |
| 公開日 | 2017-7-26 |
| DOI | 10.1016/j.cels.2017.06.004 |
| PII | S2405-4712(17)30232-6 |
| PMID | 28734827 |
| MeSH | Animals Basic Helix-Loop-Helix Transcription Factors / genetics* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics* Gene Knockout Techniques Lipid Droplets Lipoproteins / metabolism* Particle Size Proteomics RNA Interference Sequence Analysis, RNA Starvation / metabolism* Vitellogenins / genetics |
| IF | 8.673 |
| 引用数 | 13 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1978 |