RRC ID |
53939
|
著者 |
Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M.
|
タイトル |
Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans.
|
ジャーナル |
Cell Rep
|
Abstract |
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and disease. Thus far, it has proven difficult to develop successful treatment strategies for diseases that are caused by mtDNA instability. To address this issue, we developed a model of mtDNA disease in the nematode C. elegans, an animal model that can rapidly be screened for genes and biological pathways that reduce mitochondrial pathology. These worms recapitulate all the major hallmarks of mtDNA disease in humans, including increased mtDNA instability, loss of respiration, reduced neuromuscular function, and a shortened lifespan. We found that these phenotypes could be rescued by intervening in numerous biological pathways, including IGF-1/insulin signaling, mitophagy, and the mitochondrial unfolded protein response, suggesting that it may be possible to ameliorate mtDNA disease through multiple molecular mechanisms.
|
巻・号 |
22(12)
|
ページ |
3115-3125
|
公開日 |
2018-3-20
|
DOI |
10.1016/j.celrep.2018.02.099
|
PII |
S2211-1247(18)30309-7
|
PMID |
29562168
|
PMC |
PMC6106782
|
MeSH |
Animals
Caenorhabditis elegans / metabolism*
DNA, Mitochondrial / genetics*
Disease Progression
Mice
Mitochondria / metabolism*
Models, Animal
|
IF |
8.109
|
引用数 |
5
|
リソース情報 |
線虫 |
tm4919 |