論文 - 詳細
| RRC ID | 5394 |
|---|---|
| 著者 | Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H. |
| タイトル | Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis. |
| ジャーナル | Leuk Res |
| Abstract |
The pre-B lymphoma in SL/Kh mice is a polygenic trait involving a number of host genes. In prelymphoma-stage bone marrow, transient pre-B cell expansion is induced by a host locus, Bomb1, and later followed by the emergence of a monoclonal population with a similar phenotype. To determine whether these pre-B cells represent precursors of lymphomas, we generated a congenic strain, NFS.SL/Kh-Bomb1 mice, by marker-assisted backcrossing to NFS. The congenic mice showed pre-B cell expansion, but pre-B lymphomas were not observed, even after 1 year of observation, irrespective of murine leukemia virus inoculation. Disturbed early B cell differentiation per se is not sufficient for SL/Kh lymphomagenesis. |
| 巻・号 | 32(2) |
| ページ | 309-14 |
| 公開日 | 2008-2-1 |
| DOI | 10.1016/j.leukres.2007.05.013 |
| PII | S0145-2126(07)00223-8 |
| PMID | 17617450 |
| MeSH | Animals Bone Marrow Cells / cytology* Bone Marrow Cells / virology Cell Transformation, Neoplastic / genetics* Clone Cells Flow Cytometry Gene Rearrangement, B-Lymphocyte Leukemia Virus, Murine Lymphoma, B-Cell / genetics* Lymphoma, B-Cell / virology Mice Mice, Congenic Polymerase Chain Reaction Precancerous Conditions / genetics Precancerous Conditions / virology Precursor Cells, B-Lymphoid / cytology* Precursor Cells, B-Lymphoid / virology |
| IF | 2.214 |
| 引用数 | 5 |
| WOS 分野 | HEMATOLOGY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 実験動物マウス | RBRC00222 |