| RRC ID |
5394
|
| 著者 |
Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
|
| タイトル |
Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
|
| ジャーナル |
Leuk Res
|
| Abstract |
The pre-B lymphoma in SL/Kh mice is a polygenic trait involving a number of host genes. In prelymphoma-stage bone marrow, transient pre-B cell expansion is induced by a host locus, Bomb1, and later followed by the emergence of a monoclonal population with a similar phenotype. To determine whether these pre-B cells represent precursors of lymphomas, we generated a congenic strain, NFS.SL/Kh-Bomb1 mice, by marker-assisted backcrossing to NFS. The congenic mice showed pre-B cell expansion, but pre-B lymphomas were not observed, even after 1 year of observation, irrespective of murine leukemia virus inoculation. Disturbed early B cell differentiation per se is not sufficient for SL/Kh lymphomagenesis.
|
| 巻・号 |
32(2)
|
| ページ |
309-14
|
| 公開日 |
2008-2-1
|
| DOI |
10.1016/j.leukres.2007.05.013
|
| PII |
S0145-2126(07)00223-8
|
| PMID |
17617450
|
| MeSH |
Animals
Bone Marrow Cells / cytology*
Bone Marrow Cells / virology
Cell Transformation, Neoplastic / genetics*
Clone Cells
Flow Cytometry
Gene Rearrangement, B-Lymphocyte
Leukemia Virus, Murine
Lymphoma, B-Cell / genetics*
Lymphoma, B-Cell / virology
Mice
Mice, Congenic
Polymerase Chain Reaction
Precancerous Conditions / genetics
Precancerous Conditions / virology
Precursor Cells, B-Lymphoid / cytology*
Precursor Cells, B-Lymphoid / virology
|
| IF |
2.214
|
| 引用数 |
5
|
|
WOS 分野
|
HEMATOLOGY
ONCOLOGY
|
| リソース情報 |
| 実験動物マウス |
RBRC00222 |
