論文 - 詳細
| RRC ID | 53941 |
|---|---|
| 著者 | Galimov ER, Pryor RE, Poole SE, Benedetto A, Pincus Z, Gems D. |
| タイトル | Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death. |
| ジャーナル | Cell Rep |
| Abstract |
Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+ release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+ influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. VIDEO ABSTRACT. |
| 巻・号 | 22(10) |
| ページ | 2730-2741 |
| 公開日 | 2018-3-6 |
| DOI | 10.1016/j.celrep.2018.02.050 |
| PII | S2211-1247(18)30231-6 |
| PMID | 29514100 |
| PMC | PMC5863043 |
| MeSH | Adenosine Triphosphate / metabolism Aging / pathology Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Calcium Signaling Death Fluorescence Insulin / metabolism Insulin-Like Growth Factor I / metabolism Intestines / pathology* Models, Biological Muscle Contraction Muscles / pathology Mutation / genetics Necrosis Receptor, Insulin / genetics Rigor Mortis / pathology* |
| IF | 8.109 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 70 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm690 |