Reference - Detail
| RRC ID | 53942 |
|---|---|
| Author | Matsunaga Y, Matsukawa T, Iwasaki T, Nagata K, Kawano T. |
| Title | Comparison of physiological functions of antagonistic insulin-like peptides, INS-23 and INS-18, in Caenorhabditis elegans. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
In Caenorhabditis elgans, insulin-like peptides have significant roles in modulating larval diapause and adult lifespan via the insulin/IGF-1 signaling (IIS) pathway. Although 40 insulin-like peptides (ILPs) have been identified, it remains unknown how ILPs act as either agonists or antagonists for their sole receptor, DAF-2. Here we found 1) INS-23 functions as an antagonistic ILP to promote larval diapause through the IIS pathway like a DAF-2 antagonist, INS-18, 2) INS-23 and INS-18 have similar biochemical functions. In addition, our molecular modeling suggests that INS-23 and INS-18 have characteristic insertions in the B-domain, which are crucial for the recognition of the insulin receptor, when compared with DAF-2 agonists. These characteristic insertions in the B-domain of INS-23 and INS-18 would modulate their intermolecular interactions with the DAF-2 receptor, which may lead these molecules to act as antagonistic ligands. Our study provides new insight into the function and structure of ILPs. |
| Volume | 82(1) |
| Pages | 90-96 |
| Published | 2018-1-1 |
| DOI | 10.1080/09168451.2017.1415749 |
| PMID | 29303423 |
| MeSH | Animals Caenorhabditis elegans Insulin-Like Growth Factor I / pharmacology* Peptide Hormones / physiology* Signal Transduction / drug effects |
| IF | 1.516 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm339 tm1875 |