論文 - 詳細
| RRC ID | 53947 |
|---|---|
| 著者 | Tang W, Seth M, Tu S, Shen EZ, Li Q, Shirayama M, Weng Z, Mello CC. |
| タイトル | A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans. |
| ジャーナル | Dev Cell |
| Abstract |
In metazoans, Piwi-related Argonaute proteins engage piRNAs (Piwi-interacting small RNAs) to defend the genome against invasive nucleic acids, such as transposable elements. Yet many organisms-including worms and humans-express thousands of piRNAs that do not target transposons, suggesting that piRNA function extends beyond genome defense. Here, we show that the X chromosome-derived piRNA 21ux-1 downregulates XOL-1 (XO Lethal), a master regulator of X chromosome dosage compensation and sex determination in Caenorhabditis elegans. Mutations in 21ux-1 and several Piwi-pathway components sensitize hermaphrodites to dosage compensation and sex determination defects. We show that the piRNA pathway also targets xol-1 in C. briggsae, a nematode species related to C. elegans. Our findings reveal physiologically important piRNA-mRNA interactions, raising the possibility that piRNAs function broadly to ensure robust gene expression and germline development. |
| 巻・号 | 44(6) |
| ページ | 762-770.e3 |
| 公開日 | 2018-3-26 |
| DOI | 10.1016/j.devcel.2018.01.025 |
| PII | S1534-5807(18)30060-1 |
| PMID | 29456136 |
| PMC | PMC5991626 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Dosage Compensation, Genetic* Gene Expression Regulation* Phenotype RNA, Small Interfering / genetics* Sex Chromosomes* Sex Determination Analysis* |
| IF | 10.092 |
| 引用数 | 11 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 27 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm872 |