RRC ID 53973
著者 Ogura Y, Wen FL, Sami MM, Shibata T, Hayashi S.
タイトル A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination.
ジャーナル Dev Cell
Abstract The dynamics of extracellular signal-regulated kinase (ERK) signaling underlies its versatile functions in cell differentiation, cell proliferation, and cell motility. Classical studies in Drosophila established that a gradient of epidermal growth factor receptor (EGFR)-ERK signaling is essential for these cellular responses. However, we challenge this view by the real-time monitoring of ERK activation; we show that a switch-like ERK activation is essential for the invagination movement of the Drosophila tracheal placode. This switch-like ERK activation stems from the positive feedback regulation of the EGFR-ERK signaling and a resultant relay of EGFR-ERK signaling among tracheal cells. A key transcription factor Trachealess (Trh) permissively regulates the iteration of the relay, and the ERK activation becomes graded in trh mutant. A mathematical model based on these observations and a molecular link between ERK activation dynamics and myosin shows that the relay mechanism efficiently promotes epithelial invagination while the gradient mechanism does not.
巻・号 46(2)
ページ 162-172.e5
公開日 2018-7-16
DOI 10.1016/j.devcel.2018.06.004
PII S1534-5807(18)30458-1
PMID 29983336
MeSH Animals Cell Movement Cell Proliferation Drosophila / metabolism Drosophila Proteins / metabolism* Epidermal Growth Factor / metabolism ErbB Receptors / metabolism* Extracellular Signal-Regulated MAP Kinases / metabolism MAP Kinase Signaling System / physiology* Myosins / metabolism Phosphorylation Receptors, Invertebrate Peptide / metabolism* Rho Factor / metabolism Transcription Factors / metabolism
IF 10.092
引用数 14
リソース情報
ショウジョウバエ