論文 - 詳細
RRC ID | 53973 |
---|---|
著者 | Ogura Y, Wen FL, Sami MM, Shibata T, Hayashi S. |
タイトル | A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination. |
ジャーナル | Dev Cell |
Abstract |
The dynamics of extracellular signal-regulated kinase (ERK) signaling underlies its versatile functions in cell differentiation, cell proliferation, and cell motility. Classical studies in Drosophila established that a gradient of epidermal growth factor receptor (EGFR)-ERK signaling is essential for these cellular responses. However, we challenge this view by the real-time monitoring of ERK activation; we show that a switch-like ERK activation is essential for the invagination movement of the Drosophila tracheal placode. This switch-like ERK activation stems from the positive feedback regulation of the EGFR-ERK signaling and a resultant relay of EGFR-ERK signaling among tracheal cells. A key transcription factor Trachealess (Trh) permissively regulates the iteration of the relay, and the ERK activation becomes graded in trh mutant. A mathematical model based on these observations and a molecular link between ERK activation dynamics and myosin shows that the relay mechanism efficiently promotes epithelial invagination while the gradient mechanism does not. |
巻・号 | 46(2) |
ページ | 162-172.e5 |
公開日 | 2018-7-16 |
DOI | 10.1016/j.devcel.2018.06.004 |
PII | S1534-5807(18)30458-1 |
PMID | 29983336 |
MeSH | Animals Cell Movement Cell Proliferation Drosophila / metabolism Drosophila Proteins / metabolism* Epidermal Growth Factor / metabolism ErbB Receptors / metabolism* Extracellular Signal-Regulated MAP Kinases / metabolism MAP Kinase Signaling System / physiology* Myosins / metabolism Phosphorylation Receptors, Invertebrate Peptide / metabolism* Rho Factor / metabolism Transcription Factors / metabolism |
IF | 10.092 |
引用数 | 14 |
リソース情報 | |
ショウジョウバエ |