論文 - 詳細
| RRC ID | 53978 |
|---|---|
| 著者 | Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM 3rd, Xiang YK, Yasuda R, Chen B, Shen K. |
| タイトル | A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. |
| ジャーナル | Dev Cell |
| Abstract |
Proper morphogenesis of dendrites plays a fundamental role in the establishment of neural circuits. The molecular mechanism by which dendrites grow highly complex branches is not well understood. Here, using the Caenorhabditis elegans PVD neuron, we demonstrate that high-order dendritic branching requires actin polymerization driven by coordinated interactions between two membrane proteins, DMA-1 and HPO-30, with their cytoplasmic interactors, the RacGEF TIAM-1 and the actin nucleation promotion factor WAVE regulatory complex (WRC). The dendrite branching receptor DMA-1 directly binds to the PDZ domain of TIAM-1, while the claudin-like protein HPO-30 directly interacts with the WRC. On dendrites, DMA-1 and HPO-30 form a receptor-associated signaling complex to bring TIAM-1 and the WRC to close proximity, leading to elevated assembly of F-actin needed to drive high-order dendrite branching. The synergistic activation of F-actin assembly by scaffolding distinct actin regulators might represent a general mechanism in promoting complex dendrite arborization. |
| 巻・号 | 45(3) |
| ページ | 362-375.e3 |
| 公開日 | 2018-5-7 |
| DOI | 10.1016/j.devcel.2018.04.008 |
| PII | S1534-5807(18)30283-1 |
| PMID | 29738713 |
| PMC | PMC6292511 |
| MeSH | Actin Cytoskeleton / genetics Actin Cytoskeleton / metabolism* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Membrane / metabolism Dendrites / genetics Dendrites / metabolism* Membrane Proteins / genetics Membrane Proteins / metabolism Morphogenesis / physiology* Neurogenesis / physiology* Sensory Receptor Cells / metabolism* Signal Transduction |
| IF | 10.092 |
| 引用数 | 16 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1556 |