論文 - 詳細
| RRC ID | 53998 |
|---|---|
| 著者 | Ishigami K, Nosho K, Koide H, Kanno S, Mitsuhashi K, Igarashi H, Shitani M, Motoya M, Kimura Y, Hasegawa T, Kaneto H, Takemasa I, Suzuki H, Nakase H. |
| タイトル | MicroRNA-31 reflects IL-6 expression in cancer tissue and is related with poor prognosis in bile duct cancer. |
| ジャーナル | Carcinogenesis |
| Abstract |
Bile duct cancer is a highly aggressive malignancy wherein early diagnosis is difficult and few treatment options are available. MicroRNA-31 (miR-31) is reported to be related with survival in patients with gastrointestinal cancers; however, the regulatory mechanism of miR-31 and association between miR-31 expression and survival in patients with bile duct cancer cases have not been established. Thus, we evaluated miR-31 expression in bile duct cancer tissues and assessed its relationship with prognosis. Additionally, we examined the effects of several cytokines on miR-31 expression. The study included 81 samples of bile duct cancer tissues. MiR-31 expression in bile duct cancer cells was significantly higher than that in normal bile duct epithelial cells (P = 0.038). There were no significant associations between miR-31 expression and clinical or pathological characteristics, except for tumour size (P = 0.012). In Kaplan-Meier analysis, high miR-31 expression was significantly associated with shorter survival (log-rank test, P = 0.0082). In multivariate Cox regression analysis, high miR-31 expression was significantly associated with prognosis (P = 0.043), independent of clinical or pathological features. Interleukin-6 (IL-6) significantly promoted miR-31 expression and cell proliferation in a dose-dependent manner, and the inhibition of STAT-3 signalling significantly suppressed miR-31 expression and cell proliferation. In conclusion, high expression was significantly associated with poor prognosis in bile duct cancer patients. The IL-6-STAT-3 signalling regulated bile duct cancer cell proliferation and miR-31 expression. Our findings suggest that miR-31 may be a promising biomarker that reflects IL-6 expression in bile duct cancer tissues and predicts poor prognosis. |
| 巻・号 | 39(9) |
| ページ | 1127-1134 |
| 公開日 | 2018-9-21 |
| DOI | 10.1093/carcin/bgy075 |
| PII | 5025674 |
| PMID | 29860474 |
| MeSH | Aged Bile Duct Neoplasms / genetics* Bile Duct Neoplasms / mortality Bile Duct Neoplasms / pathology Cell Line, Tumor Cell Proliferation / genetics Cholangiocarcinoma / genetics* Cholangiocarcinoma / mortality Cholangiocarcinoma / pathology Female Gallbladder Neoplasms / genetics* Gallbladder Neoplasms / mortality Gallbladder Neoplasms / pathology Humans Interleukin-6 / biosynthesis* Male MicroRNAs / genetics* Prognosis STAT3 Transcription Factor / antagonists & inhibitors |
| IF | 4.603 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | TFK-1(RCB2537) |