論文 - 詳細
| RRC ID | 54004 |
|---|---|
| 著者 | Senga S, Kobayashi N, Kawaguchi K, Ando A, Fujii H. |
| タイトル | Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells. |
| ジャーナル | Biochim Biophys Acta Mol Cell Biol Lipids |
| Abstract |
Fatty acid-binding proteins (FABPs) are involved in binding and storing hydrophobic ligands such as long-chain fatty acids, as well as transporting them to the appropriate compartments in the cell. Epidermal fatty acid-binding protein (FABP5) is an intracellular lipid-binding protein that is abundantly expressed in adipocytes and macrophages. Previous studies have revealed that the FABP5 expression level is closely related to malignancy in various types of cancer. However, its precise functions in the metabolisms of cancer cells remain unclear. Here, we revealed that FABP5 knockdown significantly induced downregulation of the genes expression, such as hormone-sensitive lipase (HSL), monoacylglycerol lipase (MAGL), elongation of long-chain fatty acid member 6 (Elovl6), and acyl-CoA synthetase long-chain family member 1 (ACSL1), which are involved in altered lipid metabolism, lipolysis, and de novo FA synthesis in highly aggressive prostate and breast cancer cells. Moreover, we demonstrated that FABP5 induced inflammation and cytokine production through the nuclear factor-kappa B signaling pathway activated by reactive oxygen species and protein kinase C in PC-3 and MDA-MB-231 cells. Thus, FABP5 might regulate lipid quality and/or quantity to promote aggressiveness such as cell growth, invasiveness, survival, and inflammation in prostate and breast cancer cells. In the present study, we have revealed for the first time that high expression of FABP5 plays a critical role in alterations of lipid metabolism, leading to cancer development and metastasis in highly aggressive prostate and breast cancer cells. |
| 巻・号 | 1863(9) |
| ページ | 1057-1067 |
| 公開日 | 2018-9-1 |
| DOI | 10.1016/j.bbalip.2018.06.010 |
| PII | S1388-1981(18)30133-1 |
| PMID | 29906613 |
| MeSH | Acetyltransferases / genetics Acetyltransferases / metabolism Cell Line, Tumor Coenzyme A Ligases / genetics Coenzyme A Ligases / metabolism Cytokines / genetics Cytokines / metabolism Fatty Acid Elongases Fatty Acid-Binding Proteins / antagonists & inhibitors Fatty Acid-Binding Proteins / genetics* Fatty Acid-Binding Proteins / metabolism Fatty Acids / biosynthesis* Female Gene Expression Regulation, Neoplastic* Humans Lipid Droplets / chemistry Lipid Droplets / metabolism Lipolysis Male Mammary Glands, Human / metabolism* Mammary Glands, Human / pathology Monoacylglycerol Lipases / genetics Monoacylglycerol Lipases / metabolism NF-kappa B / genetics* NF-kappa B / metabolism Prostate / metabolism* Prostate / pathology Protein Kinase C / genetics Protein Kinase C / metabolism RNA, Small Interfering / genetics RNA, Small Interfering / metabolism Reactive Oxygen Species / metabolism Signal Transduction Sterol Esterase / genetics Sterol Esterase / metabolism |
| IF | 4.402 |
| 引用数 | 14 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| ヒト・動物細胞 | PC-3(RCB2145) |