Reference - Detail
|Author||Hagiwara K, Tobisawa Y, Kaya T, Kaneko T, Hatakeyama S, Mori K, Hashimoto Y, Koie T, Suda Y, Ohyama C, Yoneyama T.|
|Title||Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.|
|Journal||Int J Mol Sci|
Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen-glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be applied as a diagnostic and prognostic marker of prostate cancer (PCa). Between 2007 and 2016, serum PSA-Gi levels before prostate biopsy (Pbx) were measured in 184 biopsy-proven benign prostatic hyperplasia patients and 244 PCa patients using an automated lectin-antibody immunoassay. WFA-reactivity on tumor was analyzed in 260 radical prostatectomy (RP) patients. Diagnostic and prognostic performance of serum PSA-Gi was evaluated using area under the receiver-operator characteristic curve (AUC). Prognostic performance of WFA-reactivity on tumor was evaluated via Cox proportional hazards regression analysis and nomogram. The AUC of serum PSA-Gi detecting PCa and predicting Pbx Grade Group (GG) 3 and GG ≥ 3 after RP was much higher than those of conventional PSA. Multivariate analysis showed that WFA-reactivity on prostate tumor was an independent risk factor of PSA recurrence. The nomogram was a strong model for predicting PSA-free survival provability with a c-index ≥0.7. Serum PSA-Gi levels and WFA-reactivity on prostate tumor may be a novel diagnostic and pre- and post-operative prognostic biomarkers of PCa, respectively.
|MeSH||Adult Aged Aged, 80 and over Area Under Curve Biomarkers, Tumor / blood* Biopsy Glycosylation Humans Immunohistochemistry Male Middle Aged Multivariate Analysis Neoplasm Grading Neoplasm Recurrence, Local / pathology Plant Lectins / metabolism* Polysaccharides / metabolism* Prognosis Prostate / pathology Prostate / surgery Prostate-Specific Antigen / blood Prostate-Specific Antigen / metabolism* Prostatectomy Prostatic Hyperplasia / blood Prostatic Hyperplasia / pathology Prostatic Neoplasms / blood* Prostatic Neoplasms / diagnosis* Prostatic Neoplasms / pathology Prostatic Neoplasms / surgery ROC Curve Receptors, N-Acetylglucosamine / metabolism* Risk Factors|
|Human and Animal Cells||LNCap.FGC(RCB2144)|