RRC ID 54021
Author Hagiwara K, Tobisawa Y, Kaya T, Kaneko T, Hatakeyama S, Mori K, Hashimoto Y, Koie T, Suda Y, Ohyama C, Yoneyama T.
Title Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.
Journal Int J Mol Sci
Abstract Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen-glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be applied as a diagnostic and prognostic marker of prostate cancer (PCa). Between 2007 and 2016, serum PSA-Gi levels before prostate biopsy (Pbx) were measured in 184 biopsy-proven benign prostatic hyperplasia patients and 244 PCa patients using an automated lectin-antibody immunoassay. WFA-reactivity on tumor was analyzed in 260 radical prostatectomy (RP) patients. Diagnostic and prognostic performance of serum PSA-Gi was evaluated using area under the receiver-operator characteristic curve (AUC). Prognostic performance of WFA-reactivity on tumor was evaluated via Cox proportional hazards regression analysis and nomogram. The AUC of serum PSA-Gi detecting PCa and predicting Pbx Grade Group (GG) 3 and GG ≥ 3 after RP was much higher than those of conventional PSA. Multivariate analysis showed that WFA-reactivity on prostate tumor was an independent risk factor of PSA recurrence. The nomogram was a strong model for predicting PSA-free survival provability with a c-index ≥0.7. Serum PSA-Gi levels and WFA-reactivity on prostate tumor may be a novel diagnostic and pre- and post-operative prognostic biomarkers of PCa, respectively.
Volume 18(2)
Published 2017-1-26
DOI 10.3390/ijms18020261
PII ijms18020261
PMID 28134773
PMC PMC5343797
MeSH Adult Aged Aged, 80 and over Area Under Curve Biomarkers, Tumor / blood* Biopsy Glycosylation Humans Immunohistochemistry Male Middle Aged Multivariate Analysis Neoplasm Grading Neoplasm Recurrence, Local / pathology Plant Lectins / metabolism* Polysaccharides / metabolism* Prognosis Prostate / pathology Prostate / surgery Prostate-Specific Antigen / blood Prostate-Specific Antigen / metabolism* Prostatectomy Prostatic Hyperplasia / blood Prostatic Hyperplasia / pathology Prostatic Neoplasms / blood* Prostatic Neoplasms / diagnosis* Prostatic Neoplasms / pathology Prostatic Neoplasms / surgery ROC Curve Receptors, N-Acetylglucosamine / metabolism* Risk Factors
IF 4.556
Times Cited 17
Human and Animal Cells LNCap.FGC(RCB2144)