| RRC ID |
54048
|
| 著者 |
Kobayashi M, Kawashima H, Takemori K, Ito H, Murai A, Masuda S, Yamada K, Uemura D, Horio F.
|
| タイトル |
Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-A(y) mice.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
(-)-Ternatin is a highly methylated cyclic heptapeptide isolated from mushroom Coriolus versicolor. Ternatin has an inhibitory effect on fat accumulation in 3T3-L1 adipocytes. [D-Leu(7)]ternatin, a ternatin derivative, also inhibited fat accumulation in 3T3-L1 cells, although the effectiveness of [D-Leu(7)]ternatin was lower than that of ternatin. In this study, we investigated the effects of ternatin and [D-Leu(7)]ternatin on obesity and type 2 diabetes in KK-A(y) mice, an animal model for spontaneously developed type 2 diabetes. We continuously administered ternatin (8.5 or 17 nmol/day) or [D-Leu(7)]ternatin (68 nmol/day) to mice via a subcutaneous osmotic pump. Unexpectedly, neither ternatin nor [D-Leu(7)]ternatin affected body weight or adipose tissue weight in KK-A(y) mice. In contrast, it was demonstrated that both ternatin and [D-Leu(7)]ternatin suppress the development of hyperglycemia. In liver, the SREBP-1c mRNA level tended to be lower or significantly decreased in mice treated with ternatin or [D-Leu(7)]ternatin, respectively. Moreover, we found that ternatin directly lowered the SREBP-1c mRNA level in Hepa1-6 hepatocyte cells. This study showed that ternatin and [D-Leu(7)]ternatin each had a preventive effect on hyperglycemia and a suppressive effect on fatty acid synthesis in KK-A(y) mice.
|
| 巻・号 |
427(2)
|
| ページ |
299-304
|
| 公開日 |
2012-10-19
|
| DOI |
10.1016/j.bbrc.2012.09.045
|
| PII |
S0006-291X(12)01785-8
|
| PMID |
23000156
|
| MeSH |
Animals
Cell Line
Diabetes Mellitus, Experimental / drug therapy*
Diabetes Mellitus, Experimental / metabolism
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / metabolism
Fatty Acids / antagonists & inhibitors*
Hyperglycemia / drug therapy*
Liver / drug effects*
Liver / metabolism
Male
Mice
Mice, Inbred Strains
Peptides, Cyclic / administration & dosage*
|
| リソース情報 |
| ヒト・動物細胞 |
Hepa1-6(RCB1638) |
