論文 - 詳細
| RRC ID | 54048 |
|---|---|
| 著者 | Kobayashi M, Kawashima H, Takemori K, Ito H, Murai A, Masuda S, Yamada K, Uemura D, Horio F. |
| タイトル | Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-A(y) mice. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
(-)-Ternatin is a highly methylated cyclic heptapeptide isolated from mushroom Coriolus versicolor. Ternatin has an inhibitory effect on fat accumulation in 3T3-L1 adipocytes. [D-Leu(7)]ternatin, a ternatin derivative, also inhibited fat accumulation in 3T3-L1 cells, although the effectiveness of [D-Leu(7)]ternatin was lower than that of ternatin. In this study, we investigated the effects of ternatin and [D-Leu(7)]ternatin on obesity and type 2 diabetes in KK-A(y) mice, an animal model for spontaneously developed type 2 diabetes. We continuously administered ternatin (8.5 or 17 nmol/day) or [D-Leu(7)]ternatin (68 nmol/day) to mice via a subcutaneous osmotic pump. Unexpectedly, neither ternatin nor [D-Leu(7)]ternatin affected body weight or adipose tissue weight in KK-A(y) mice. In contrast, it was demonstrated that both ternatin and [D-Leu(7)]ternatin suppress the development of hyperglycemia. In liver, the SREBP-1c mRNA level tended to be lower or significantly decreased in mice treated with ternatin or [D-Leu(7)]ternatin, respectively. Moreover, we found that ternatin directly lowered the SREBP-1c mRNA level in Hepa1-6 hepatocyte cells. This study showed that ternatin and [D-Leu(7)]ternatin each had a preventive effect on hyperglycemia and a suppressive effect on fatty acid synthesis in KK-A(y) mice. |
| 巻・号 | 427(2) |
| ページ | 299-304 |
| 公開日 | 2012-10-19 |
| DOI | 10.1016/j.bbrc.2012.09.045 |
| PII | S0006-291X(12)01785-8 |
| PMID | 23000156 |
| MeSH | Animals Cell Line Diabetes Mellitus, Experimental / drug therapy* Diabetes Mellitus, Experimental / metabolism Diabetes Mellitus, Type 2 / drug therapy* Diabetes Mellitus, Type 2 / metabolism Fatty Acids / antagonists & inhibitors* Hyperglycemia / drug therapy* Liver / drug effects* Liver / metabolism Male Mice Mice, Inbred Strains Peptides, Cyclic / administration & dosage* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hepa1-6(RCB1638) |