Reference - Detail
| RRC ID | 54163 |
|---|---|
| Author | Chia KH, Fukuda T, Sofyantoro F, Matsuda T, Amai T, Shiozaki K. |
| Title | Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. |
| Journal | Elife |
| Abstract |
TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that promotes cellular macromolecular synthesis and suppresses autophagy. Amino-acid-induced activation of mammalian TORC1 is initiated by its recruitment to the RagA/B-RagC/D GTPase heterodimer, which is anchored to lysosomal membranes through the Ragulator complex. We have identified in the model organism Schizosaccharomyces pombe a Ragulator-like complex that tethers the Gtr1-Gtr2 Rag heterodimer to the membranes of vacuoles, the lysosome equivalent in yeasts. Unexpectedly, the Ragulator-Rag complex is not required for the vacuolar targeting of TORC1, but the complex plays a crucial role in attenuating TORC1 activity independently of the Tsc1-Tsc2 complex, a known negative regulator of TORC1 signaling. The GATOR1 complex, which functions as Gtr1 GAP, is essential for the TORC1 attenuation by the Ragulator-Rag complex, suggesting that Gtr1GDP-Gtr2 on vacuolar membranes moderates TORC1 signaling for optimal cellular response to nutrients. |
| Volume | 6 |
| Published | 2017-12-4 |
| DOI | 10.7554/eLife.30880 |
| PII | 30880 |
| PMID | 29199950 |
| PMC | PMC5752196 |
| MeSH | Mechanistic Target of Rapamycin Complex 1 / antagonists & inhibitors* Monomeric GTP-Binding Proteins / metabolism* Protein Multimerization Protein Transport Schizosaccharomyces / growth & development* Vacuoles / metabolism |
| IF | 7.08 |
| Times Cited | 8 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | |