論文 - 詳細
| RRC ID | 54173 |
|---|---|
| 著者 | Orlandi C, Omori Y, Wang Y, Cao Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA. |
| タイトル | Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. |
| ジャーナル | Cell Rep |
| Abstract |
Establishing synaptic contacts between neurons is paramount for nervous system function. This process involves transsynaptic interactions between a host of cell adhesion molecules that act in cooperation with the proteins of the extracellular matrix to specify unique physiological properties of individual synaptic connections. However, understanding of the molecular mechanisms that generate functional diversity in an input-specific fashion is limited. In this study, we identify that major components of the extracellular matrix proteins present in the synaptic cleft-members of the heparan sulfate proteoglycan (HSPG) family-associate with the GPR158/179 group of orphan receptors. Using the mammalian retina as a model system, we demonstrate that the HSPG member Pikachurin, released by photoreceptors, recruits a key post-synaptic signaling complex of downstream ON-bipolar neurons in coordination with the pre-synaptic dystroglycan glycoprotein complex. We further demonstrate that this transsynaptic assembly plays an essential role in synaptic transmission of photoreceptor signals. |
| 巻・号 | 25(1) |
| ページ | 130-145.e5 |
| 公開日 | 2018-10-2 |
| DOI | 10.1016/j.celrep.2018.08.068 |
| PII | S2211-1247(18)31372-X |
| PMID | 30282023 |
| PMC | PMC6203450 |
| MeSH | Animals Carrier Proteins / metabolism* Dystroglycans / metabolism* Extracellular Matrix / metabolism HEK293 Cells Humans Mice Mice, Knockout Nerve Tissue Proteins / metabolism* Photoreceptor Cells / metabolism* Protein Binding Receptors, G-Protein-Coupled / metabolism* Synapses / metabolism Synaptic Transmission / physiology |
| IF | 8.109 |
| 引用数 | 13 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC05552 |