論文 - 詳細
| RRC ID | 54180 |
|---|---|
| 著者 | Nonaka S, Kawamura K, Hori A, Salim E, Fukushima K, Nakanishi Y, Kuraishi T. |
| タイトル | Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
The Drosophila Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the Toll-1 receptor, only Spätzle (Spz) has been identified and characterized. We previously reported that Drosophila larva-derived tissue extract contains ligand activity for the Toll-1 receptor, which differs from Spz based on the observation that larval extract prepared from spz mutants possessed full ligand activity. Here, we demonstrate that Spz5, a member of the Spz family of proteins, functions as a ligand for the Toll-1 receptor. Processing of Spz5 by Furin protease, which is known to be important for ligand activity of Spz5 to Toll-6, is not required for its function to the Toll-1 receptor. By generating a spz5 null mutant, we further showed that the Toll-1 ligand activity of larva-derived extract is mainly derived from Spz5. Finally, we found a genetic interaction between spz and spz5 in terms of developmental processes. This study identified a novel ligand for the Drosophila Toll-1 receptor, providing evidence that Toll-1 is a multi-ligand receptor, similar to the mammalian Toll-like receptor. |
| 巻・号 | 506(3) |
| ページ | 510-515 |
| 公開日 | 2018-11-30 |
| DOI | 10.1016/j.bbrc.2018.10.096 |
| PII | S0006-291X(18)32252-6 |
| PMID | 30361090 |
| MeSH | Animals Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Epistasis, Genetic Larva / metabolism Ligands Proteolysis Tissue Extracts Toll-Like Receptors / metabolism* |
| IF | 2.985 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | CAS-0001 |