RRC ID 54276
著者 Sato M, Kornberg TB.
タイトル FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system.
ジャーナル Dev Cell
Abstract The Drosophila adult has a complex tracheal system that forms during the pupal period. We have studied the derivation of part of this system, the air sacs of the dorsal thorax. During the third larval instar, air sac precursor cells bud from a tracheal branch in response to FGF, and then they proliferate and migrate to the adepithelial layer of the wing imaginal disc. In addition, FGF induces these air sac precursors to extend cytoneme-like filopodia to FGF-expressing cells. These findings provide evidence that FGF is a mitogen in Drosophila, correlate growth factor signaling with filopodial contact between signaling and responding cells, and suggest that FGF can act on differentiated tracheal cells to induce a novel behavior and role.
巻・号 3(2)
ページ 195-207
公開日 2002-8-1
DOI 10.1016/s1534-5807(02)00202-2
PII S1534-5807(02)00202-2
PMID 12194851
MeSH Actins / metabolism Air Sacs / cytology Air Sacs / growth & development* Air Sacs / metabolism Animals Cell Communication / drug effects Cell Communication / physiology Cell Differentiation / drug effects Cell Differentiation / physiology Cell Division / drug effects Cell Division / physiology* Cell Movement / drug effects Cell Movement / physiology Chemotactic Factors / metabolism* Chemotactic Factors / pharmacology Drosophila / cytology Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins* Epithelial Cells / cytology Epithelial Cells / drug effects Epithelial Cells / metabolism Fibroblast Growth Factors / metabolism* Fibroblast Growth Factors / pharmacology Gene Expression Regulation, Developmental / physiology Insect Proteins / genetics Insect Proteins / metabolism Protein-Tyrosine Kinases* Pseudopodia / drug effects Pseudopodia / metabolism Pseudopodia / ultrastructure Pupa / cytology Pupa / growth & development* Pupa / metabolism Receptors, Fibroblast Growth Factor / drug effects Receptors, Fibroblast Growth Factor / genetics Receptors, Fibroblast Growth Factor / metabolism Signal Transduction / drug effects Signal Transduction / physiology Stem Cells / cytology Stem Cells / drug effects Stem Cells / metabolism Trachea / cytology Trachea / growth & development* Trachea / metabolism Wings, Animal / cytology Wings, Animal / growth & development* Wings, Animal / metabolism
IF 10.092
引用数 156
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