RRC ID 54277
著者 Klämbt C, Glazer L, Shilo BZ.
タイトル breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.
ジャーナル Genes Dev
Abstract A Drosophila homolog of the fibroblast growth factor (FGF) receptor was isolated and structurally characterized. After EMS mutagenesis or imprecise excisions of marked P elements inserted upstream to the gene, a phenotypic series of mutations in the locus was isolated. The mutants exhibit defects in the two embryonic tissues in which the receptor is expressed: the tracheal system and the midline. The tracheal cells fail to migrate in severe mutants and remain within the tracheal pits. Hypomorphic alleles exhibit partial migration of all tracheal branches; thus, the locus was termed breathless (btl). In the midline of the mutant embryos, the posterior pair of midline glial cells begins to migrate anteriorly, but fails to reach the posterior commissure. Abnormalities in cell migration appear to be a common denominator for the btl defects in these two disparate tissues. In hypomorphic mutants the cells exhibit partial migration but follow the normal tracts, suggesting that the presence of this receptor is essential for the ability of the migrating cells to recognize external guiding cues.
巻・号 6(9)
ページ 1668-78
公開日 1992-9-1
DOI 10.1101/gad.6.9.1668
PMID 1325393
MeSH Amino Acid Sequence Animals Base Sequence Cell Movement / physiology Drosophila / embryology* Drosophila Proteins* Fibroblast Growth Factors / physiology* Molecular Sequence Data Neuroglia / cytology* Nucleic Acid Hybridization Protein-Tyrosine Kinases / chemistry Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / physiology* Receptors, Cell Surface / chemistry Receptors, Cell Surface / genetics Receptors, Cell Surface / physiology* Receptors, Fibroblast Growth Factor Restriction Mapping Trachea / cytology Trachea / embryology
IF 9.527
引用数 347
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