RRC ID 54279
著者 Imam F, Sutherland D, Huang W, Krasnow MA.
タイトル stumps, a Drosophila gene required for fibroblast growth factor (FGF)-directed migrations of tracheal and mesodermal cells.
ジャーナル Genetics
Abstract Fibroblast growth factors (FGFs) bind to FGF receptors, transmembrane tyrosine kinases that activate mitogenic, motogenic, and differentiative responses in different tissues. While there has been substantial progress in elucidating the Ras-MAP kinase pathway that mediates the differentiative responses, the signal transduction pathways that lead to directed cell migrations are not well defined. Here we describe a Drosophila gene called stumps that is required for FGF-dependent migrations of tracheal and mesodermal cells. These migrations are controlled by different FGF ligands and receptors, and they occur by different cellular mechanisms: the tracheal migrations occur as part of an epithelium whereas the mesodermal migrations are fibroblast-like. In the stumps mutant, tracheal cells fail to move out from the epithelial sacs, and only rudimentary tracheal branches form. Mesodermal cells fail in their dorsal migrations after gastrulation. The stumps mutation does not block all FGF signaling effects in these tissues: both random cell migrations and Ras-MAP kinase-mediated induction of FGF-specific effector genes occurred upon ectopic expression of the ligand or upon expression of a constitutively activated Ras protein in the migrating cells. The results suggest that stumps function promotes FGF-directed cell migrations, either by potentiating the FGF signaling process or by coupling the signal to the cellular machinery required for directed cell movement.
巻・号 152(1)
ページ 307-18
公開日 1999-5-1
DOI 10.1093/genetics/152.1.307
PMID 10224263
PMC PMC1460608
MeSH Animals Cell Movement / physiology* Chromosome Mapping Dose-Response Relationship, Drug Drosophila Proteins* Drosophila melanogaster / genetics* Fibroblast Growth Factors / genetics* Gene Expression Regulation Immunohistochemistry Insect Proteins / metabolism Mesoderm / cytology Mesoderm / physiology* Models, Biological Phenotype Signal Transduction Trachea / cytology Trachea / physiology* ras Proteins / metabolism
IF 4.015
引用数 71
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