論文 - 詳細
| RRC ID | 54365 |
|---|---|
| 著者 | Phan A, Thomas CI, Chakraborty M, Berry JA, Kamasawa N, Davis RL. |
| タイトル | Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size. |
| ジャーナル | Neuron |
| Abstract |
Stromalin, a cohesin complex protein, was recently identified as a novel memory suppressor gene, but its mechanism remained unknown. Here, we show that Stromalin functions as a negative regulator of synaptic vesicle (SV) pool size in Drosophila neurons. Stromalin knockdown in dopamine neurons during a critical developmental period enhances learning and increases SV pool size without altering the number of dopamine neurons, their axons, or synapses. The developmental effect of Stromalin knockdown persists into adulthood, leading to strengthened synaptic connections and enhanced olfactory memory acquisition in adult flies. Correcting the SV content in dopamine neuron axon terminals by impairing anterograde SV trafficking motor protein Unc104/KIF1A rescues the enhanced-learning phenotype in Stromalin knockdown flies. Our results identify a new mechanism for memory suppression and reveal that the size of the SV pool is controlled genetically and independent from other aspects of neuron structure and function through Stromalin. |
| 巻・号 | 101(1) |
| ページ | 103-118.e5 |
| 公開日 | 2019-1-2 |
| DOI | 10.1016/j.neuron.2018.11.003 |
| PII | S0896-6273(18)30994-2 |
| PMID | 30503644 |
| PMC | PMC6318033 |
| MeSH | Amino Acid Sequence Animals Animals, Genetically Modified Dopaminergic Neurons / metabolism Dopaminergic Neurons / ultrastructure Drosophila Proteins / deficiency* Drosophila Proteins / genetics Drosophila melanogaster Female Memory / physiology* Nuclear Proteins / deficiency* Nuclear Proteins / genetics Synapses / genetics Synapses / metabolism Synapses / ultrastructure Synaptic Vesicles / genetics Synaptic Vesicles / metabolism* Synaptic Vesicles / ultrastructure* |
| IF | 14.415 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 3423R-2 GFP-IR-1 DGRC#104219 DGRC#114140 DGRC#105377 |