論文 - 詳細
| RRC ID | 54396 |
|---|---|
| 著者 | Boda A, Lőrincz P, Takáts S, Csizmadia T, Tóth S, Kovács AL, Juhász G. |
| タイトル | Drosophila Arl8 is a general positive regulator of lysosomal fusion events. |
| ジャーナル | Biochim Biophys Acta Mol Cell Res |
| Abstract |
The small GTPase Arl8 is known to be involved in the periphery-directed motility of lysosomes. However, the overall importance of moving these vesicles is still poorly understood. Here we show that Drosophila Arl8 is required not only for the proper distribution of lysosomes, but also for autophagosome-lysosome fusion in starved fat cells, endosome-lysosome fusion in garland nephrocytes, and developmentally programmed secretory granule degradation (crinophagy) in salivary gland cells. Moreover, proper Arl8 localization to lysosomes depends on the shared subunits of the BLOC-1 and BORC complexes, which also promote autophagy and crinophagy. In conclusion, we demonstrate that Arl8 is responsible not only for positioning lysosomes but also acts as a general lysosomal fusion factor. |
| 巻・号 | 1866(4) |
| ページ | 533-544 |
| 公開日 | 2019-4-1 |
| DOI | 10.1016/j.bbamcr.2018.12.011 |
| PII | S0167-4889(18)30256-8 |
| PMID | 30590083 |
| MeSH | ADP-Ribosylation Factors / genetics ADP-Ribosylation Factors / metabolism ADP-Ribosylation Factors / physiology* Animals Autophagosomes / physiology Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster / physiology Drosophila melanogaster / ultrastructure Lysosomes / metabolism Lysosomes / physiology* Lysosomes / ultrastructure Membrane Fusion Protein Subunits / physiology rab GTP-Binding Proteins / physiology |
| IF | 4.739 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 17180R-1 DGRC#140948 DGRC#141970 DGRC#141824 |