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  • Search Condition : Filter (MeSH = Lysosomes / metabolism)
Species Resource Title
Mice RBRC00806 TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model.
Human and Animal Cells MIA Paca2(RCB2094) RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells.
Mice RBRC00806 Aging Differentially Affects Axonal Autophagosome Formation and Maturation.
Drosophila 7402R-1 , 7402R-2 , 7408R-2 , 7408R-3 , 10104R-2 , 10104R-3 , 6395R-1 , 6395R-2 , 3132R-1 , 3132R-3 , ... Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
C.elegans tm1200 Tubular lysosome induction couples animal starvation to healthy aging.
Zebrafish Tg(Huc:Kaede)rw0130a DHCR7 links cholesterol synthesis with neuronal development and axonal integrity.
Drosophila 1515R-1 The Ykt6-Snap29-Syx13 SNARE complex promotes crinophagy via secretory granule fusion with Lamp1 carrier vesicles.
Human and Animal Cells HeLa Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States.
Human and Animal Cells ST2(RCB0224) A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application.
Human and Animal Cells , DNA material HuH-7(RCB1366) , HCT116(RCB2979) , HeLa , A549 , pcDNA5 alpha 2M-RFP-GFP-His (RDB20287) , pcDNA5 alpha 2M-ALFA-His (RDB20288) , pcDNA5 alpha 2M-delta bait-RFP-GFP-His (RDB20289) Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins.
C.elegans tm1011 Lysosome lipid signalling from the periphery to neurons regulates longevity.
C.elegans tm1954 , tm1290 , tm7967 , tm1800 , tm1722 , tm4598 , tm11844 , tm12345 Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan.
C.elegans tm1125 SCAV-3 affects apoptotic cell degradation in Caenorhabditis elegans.
C.elegans tm2367 , tm3828 , tm2504 A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes.
C.elegans tm1595 , tm5356 , tm847 , tm2423 , tm2404 , tm3643 , tm1320 SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking.
Human and Animal Cells 293(RCB1637) , RAW 264(RCB0535) , HCT116(RCB2979) , Hep G2 , HuH-7 Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC.
Human and Animal Cells HeLa(RCB0007) , 293T(RCB2202) NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy.
Japanese macaques Hydroxynonenal Causes Hepatocyte Death by Disrupting Lysosomal Integrity in Nonalcoholic Steatohepatitis.
Drosophila 11926R-1 Rab26 controls secretory granule maturation and breakdown in Drosophila.
Arabidopsis / Cultured plant cells, genes pst18264 A unique plant ESCRT component, FREE1, regulates multivesicular body protein sorting and plant growth.