Reference - Detail
| RRC ID | 54397 |
|---|---|
| Author | Ramin M, Li Y, Chang WT, Shaw H, Rao Y. |
| Title | The peacefulness gene promotes aggression in Drosophila. |
| Journal | Mol Brain |
| Abstract |
Natural aggressiveness is commonly observed in all animal species, and is displayed frequently when animals compete for food, territory and mating. Aggression is an innate behaviour, and is influenced by both environmental and genetic factors. However, the genetics of aggression remains largely unclear. In this study, we identify the peacefulness (pfs) gene as a novel player in the control of male-male aggression in Drosophila. Mutations in pfs decreased intermale aggressiveness, but did not affect locomotor activity, olfactory avoidance response and sexual behaviours. pfs encodes for the evolutionarily conserved molybdenum cofactor (MoCo) synthesis 1 protein (Mocs1), which catalyzes the first step in the MoCo biosynthesis pathway. Neuronal-specific knockdown of pfs decreased aggressiveness. By contrast, overexpression of pfs greatly increased aggressiveness. Knocking down Cinnamon (Cin) catalyzing the final step in the MoCo synthesis pathway, caused a pfs-like aggression phenotype. In humans, inhibition of MoCo-dependent enzymes displays anti-aggressive effects. Thus, the control of aggression by Pfs-dependent MoCo pathways may be conserved throughout evolution. |
| Volume | 12(1) |
| Pages | 1 |
| Published | 2019-1-3 |
| DOI | 10.1186/s13041-018-0417-0 |
| PII | 10.1186/s13041-018-0417-0 |
| PMID | 30606245 |
| PMC | PMC6318936 |
| MeSH | Aggression / physiology* Animals Avoidance Learning Brain / metabolism Carbon-Carbon Lyases Coenzymes / biosynthesis Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / physiology* Gene Knockdown Techniques Genes, Insect* Male Metalloproteins / biosynthesis Molybdenum Cofactors Motor Activity Mutagenesis, Insertional / genetics Neurons / metabolism Nuclear Proteins / genetics* Nuclear Proteins / metabolism Pteridines Sexual Behavior, Animal Smell / physiology |
| IF | 4.686 |
| Times Cited | 2 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 7858R-1 |