RRC ID 54429
Author Duda M, Kirkland NJ, Khalilgharibi N, Tozluoglu M, Yuen AC, Carpi N, Bove A, Piel M, Charras G, Baum B, Mao Y.
Title Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress.
Journal Dev Cell
Abstract As tissues develop, they are subjected to a variety of mechanical forces. Some of these forces are instrumental in the development of tissues, while others can result in tissue damage. Despite our extensive understanding of force-guided morphogenesis, we have only a limited understanding of how tissues prevent further morphogenesis once the shape is determined after development. Here, through the development of a tissue-stretching device, we uncover a mechanosensitive pathway that regulates tissue responses to mechanical stress through the polarization of actomyosin across the tissue. We show that stretch induces the formation of linear multicellular actomyosin cables, which depend on Diaphanous for their nucleation. These stiffen the epithelium, limiting further changes in shape, and prevent fractures from propagating across the tissue. Overall, this mechanism of force-induced changes in tissue mechanical properties provides a general model of force buffering that serves to preserve the shape of tissues under conditions of mechanical stress.
Volume 48(2)
Pages 245-260.e7
Published 2019-1-28
DOI 10.1016/j.devcel.2018.12.020
PII S1534-5807(18)31088-8
PMID 30695698
PMC PMC6353629
MeSH Actomyosin / metabolism Animals Cell Shape / physiology Cytoskeletal Proteins / metabolism* Epithelium / metabolism Morphogenesis / physiology* Myosin Type II / metabolism* Stress, Mechanical*
IF 9.19
Times Cited 16
Drosophila 9901-R HMS00830 HMS00437 32018R-1 32018R-3 DGRC#110833