RRC ID 54461
Author Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.
Title TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Journal Nat Immunol
Abstract Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-beta independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-beta promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response.
Volume 4(2)
Pages 161-7
Published 2003-2
DOI 10.1038/ni886
PII ni886
PMID 12539043
MeSH Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport / genetics Adaptor Proteins, Vesicular Transport / immunology* Adaptor Proteins, Vesicular Transport / metabolism* Amino Acid Sequence Animals Antigens, Differentiation / metabolism Binding Sites Cell Line Cloning, Molecular DNA-Binding Proteins / metabolism Drosophila Proteins* Female Gene Silencing Humans Immunity, Cellular Interferon Regulatory Factor-3 Interferon-beta / biosynthesis* Male Membrane Glycoproteins / chemistry Membrane Glycoproteins / metabolism* Mice Molecular Sequence Data Myeloid Differentiation Factor 88 NF-kappa B / metabolism Pregnancy Protein Structure, Tertiary RNA, Double-Stranded / metabolism Receptors, Cell Surface / chemistry Receptors, Cell Surface / metabolism* Receptors, Immunologic / metabolism Receptors, Interleukin-1 / metabolism Sequence Homology, Amino Acid Signal Transduction Tissue Distribution Toll-Like Receptor 3 Toll-Like Receptors Transcription Factor AP-1 / metabolism Transcription Factors / metabolism
IF 23.53
Times Cited 871
Resource
DNA material human TICAM-1 expression vector (RDB16923) human TICAM-1 C Flag expression vector (RDB16925) human TICAM-1 C HA expression vector (RDB16927)