RRC ID |
54461
|
著者 |
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.
|
タイトル |
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
|
ジャーナル |
Nat Immunol
|
Abstract |
Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-beta independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-beta promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response.
|
巻・号 |
4(2)
|
ページ |
161-7
|
公開日 |
2003-2-1
|
DOI |
10.1038/ni886
|
PII |
ni886
|
PMID |
12539043
|
MeSH |
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport / genetics
Adaptor Proteins, Vesicular Transport / immunology*
Adaptor Proteins, Vesicular Transport / metabolism*
Amino Acid Sequence
Animals
Antigens, Differentiation / metabolism
Binding Sites
Cell Line
Cloning, Molecular
DNA-Binding Proteins / metabolism
Drosophila Proteins*
Female
Gene Silencing
Humans
Immunity, Cellular
Interferon Regulatory Factor-3
Interferon-beta / biosynthesis*
Male
Membrane Glycoproteins / chemistry
Membrane Glycoproteins / metabolism*
Mice
Molecular Sequence Data
Myeloid Differentiation Factor 88
NF-kappa B / metabolism
Pregnancy
Protein Structure, Tertiary
RNA, Double-Stranded / metabolism
Receptors, Cell Surface / chemistry
Receptors, Cell Surface / metabolism*
Receptors, Immunologic / metabolism
Receptors, Interleukin-1 / metabolism
Sequence Homology, Amino Acid
Signal Transduction
Tissue Distribution
Toll-Like Receptor 3
Toll-Like Receptors
Transcription Factor AP-1 / metabolism
Transcription Factors / metabolism
|
IF |
23.53
|
引用数 |
871
|
リソース情報 |
遺伝子材料 |
human TICAM-1 expression vector (RDB16923)
human TICAM-1 C Flag expression vector (RDB16925)
human TICAM-1 C HA expression vector (RDB16927) |