論文 - 詳細
| RRC ID | 54537 |
|---|---|
| 著者 | Horio N, Murata K, Yoshikawa K, Yoshihara Y, Touhara K. |
| タイトル | Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice. |
| ジャーナル | Nat Commun |
| Abstract |
Odorants are recognized by multiple olfactory receptors (ORs) and induce innate behaviors like attraction or aversion via olfactory system in mice. However, a role of an individual OR is unclear. Muscone is recognized by a few ORs including MOR215-1 and MOR214-3, and attracts male mice. Odor preference tests using MOR215-1 knockout mice revealed that MOR215-1 and other OR(s), possibly including MOR214-3, are involved in the attraction. (Z)-5-tetradecen-1-ol (Z5-14:OH) activates ~3 ORs, including Olfr288, and evokes attraction at low levels but aversion at higher levels. Olfr288 knockout mice show no attraction but aversion, suggesting Olfr288 is involved in preference for Z5-14:OH, whereas activation of other low-affinity Z5-14:OH receptors evokes aversion. Each OR appears to send a signal to a neural circuit that possesses distinct valence, leading to a certain behavior. The final output behavior with multiple ORs stimulation is determined by summation (addition or competition) of valences coded by activated ORs. |
| 巻・号 | 10(1) |
| ページ | 209 |
| 公開日 | 2019-1-14 |
| DOI | 10.1038/s41467-018-07940-1 |
| PII | 10.1038/s41467-018-07940-1 |
| PMID | 30643144 |
| PMC | PMC6331590 |
| MeSH | Animals Cycloparaffins / chemistry Cycloparaffins / metabolism Female Instinct* Male Mating Preference, Animal / physiology* Mice Mice, Inbred C57BL Mice, Knockout Odorants Olfactory Receptor Neurons / physiology* Receptors, Odorant / physiology* Smell / physiology* |
| IF | 11.878 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | B6N Mouse BAC clone B6Ng01-336J02 (RDB07573) |