RRC ID |
54537
|
著者 |
Horio N, Murata K, Yoshikawa K, Yoshihara Y, Touhara K.
|
タイトル |
Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice.
|
ジャーナル |
Nat Commun
|
Abstract |
Odorants are recognized by multiple olfactory receptors (ORs) and induce innate behaviors like attraction or aversion via olfactory system in mice. However, a role of an individual OR is unclear. Muscone is recognized by a few ORs including MOR215-1 and MOR214-3, and attracts male mice. Odor preference tests using MOR215-1 knockout mice revealed that MOR215-1 and other OR(s), possibly including MOR214-3, are involved in the attraction. (Z)-5-tetradecen-1-ol (Z5-14:OH) activates ~3 ORs, including Olfr288, and evokes attraction at low levels but aversion at higher levels. Olfr288 knockout mice show no attraction but aversion, suggesting Olfr288 is involved in preference for Z5-14:OH, whereas activation of other low-affinity Z5-14:OH receptors evokes aversion. Each OR appears to send a signal to a neural circuit that possesses distinct valence, leading to a certain behavior. The final output behavior with multiple ORs stimulation is determined by summation (addition or competition) of valences coded by activated ORs.
|
巻・号 |
10(1)
|
ページ |
209
|
公開日 |
2019-1-14
|
DOI |
10.1038/s41467-018-07940-1
|
PII |
10.1038/s41467-018-07940-1
|
PMID |
30643144
|
PMC |
PMC6331590
|
MeSH |
Animals
Cycloparaffins / chemistry
Cycloparaffins / metabolism
Female
Instinct*
Male
Mating Preference, Animal / physiology*
Mice
Mice, Inbred C57BL
Mice, Knockout
Odorants
Olfactory Receptor Neurons / physiology*
Receptors, Odorant / physiology*
Smell / physiology*
|
IF |
11.878
|
引用数 |
4
|
リソース情報 |
遺伝子材料 |
B6N Mouse BAC clone B6Ng01-336J02 (RDB07573) |