論文 - 詳細
| RRC ID | 54754 |
|---|---|
| 著者 | Yu J, Kim HM, Kim KP, Son Y, Kim MS, Park KS. |
| タイトル | Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-β). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine-1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-β. However, the roles of intrinsic lipid kinases of BM-MSCs in the stem cell migration are unclear. Here, we demonstrated that ceramide kinase mediates the chemotactic migration of BM-MSCs in response to SP, SDF-1, or TGF-β. Furthermore, a specific inhibitor of ceramide kinase inhibited TGF-β-induced migration of BM-MSCs and N-cadherin that is necessary for BM-MSCs migration in response to TGF-β. Therefore, these results suggest that the intracellular ceramide kinase is required for the BM-MSCs migration and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation. |
| 巻・号 | 508(2) |
| ページ | 361-367 |
| 公開日 | 2019-1-8 |
| DOI | 10.1016/j.bbrc.2018.11.154 |
| PII | S0006-291X(18)32589-0 |
| PMID | 30502084 |
| MeSH | Animals Antigens, CD / genetics Cadherins / genetics Cell Line Cell Movement / physiology* Ceramides / metabolism Chemokine CXCL12 / metabolism Chemotaxis / physiology Gene Expression Regulation Humans Mesenchymal Stem Cells / physiology* Mice Phosphotransferases (Alcohol Group Acceptor) / metabolism* RNA, Messenger / genetics RNA, Messenger / metabolism Substance P / metabolism Transforming Growth Factor beta / metabolism |
| IF | 2.705 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |