論文 - 詳細
| RRC ID | 54755 |
|---|---|
| 著者 | Kato N, Sato Y, Kamataki A, Fukase M, Uchigasaki S, Kurose A. |
| タイトル | PIK3CA hotspot mutations and cyclooxygenase-2 expression in ovarian clear cell carcinomas: a close association with stromal features. |
| ジャーナル | Hum Pathol |
| Abstract |
Ovarian clear cell carcinomas (CCCs) have 2 distinct stromas: a hyalinized/mucoid stroma and a plasma cell-rich inflammatory stroma. Clinically, CCC is the most common ovarian cancer associated with thromboembolism. Recent studies suggested a potential role of PIK3CA mutation in the cyclooxygenase (COX) pathway, which mediates inflammation or hemostasis. In the present study, 54 ovarian CCCs and 3 CCC cell lines were analyzed for PIK3CA hotspot mutation and COX-2 expression with special reference to stromal features. Among the 54 CCCs, 20 (37.0%) and 8 (14.8%) were classified as CCCs with a hyalinized/mucoid stroma and an inflammatory stroma, respectively. PIK3CA mutation was identified in 11 (55%) of the 20 CCCs with a hyalinized/mucoid stroma, but not in any of the 8 CCCs with an inflammatory stroma. In contrast, COX-2 expression was frequent in CCCs with an inflammatory stroma (1/20 [5%] versus 7/8 [87.5%], respectively). Such a relationship between the PIK3CA mutation, COX-2 expression, and stromal features was repeated in the 3 CCC cell lines. Thromboembolism was noted in 9 (16.7%) of the 54 CCC patients, and it was more frequent in CCCs with a hyalinized/mucoid stroma (7/20 [35%]) than in those with an inflammatory stroma (0/8 [0%]). In conclusion, there is a difference in PIK3CA mutation, COX-2 expression, and paraneoplastic thromboembolism between CCCs with a different stroma. It is suggested that a different stromal feature, either hyalinized/mucoid change or inflammation, represents a different molecular genetic background or hemostatic potential in ovarian CCCs. |
| 巻・号 | 86 |
| ページ | 32-37 |
| 公開日 | 2019-4-1 |
| DOI | 10.1016/j.humpath.2018.11.013 |
| PII | S0046-8177(18)30464-7 |
| PMID | 30496799 |
| MeSH | Adenocarcinoma, Clear Cell / genetics* Adenocarcinoma, Clear Cell / metabolism Adenocarcinoma, Clear Cell / pathology Cell Line, Tumor Class I Phosphatidylinositol 3-Kinases / genetics* Cyclooxygenase 2 / metabolism* DNA Mutational Analysis Female Humans Mutation* Ovarian Neoplasms / genetics* Ovarian Neoplasms / metabolism Ovarian Neoplasms / pathology Ovary / metabolism Ovary / pathology* Stromal Cells / metabolism Stromal Cells / pathology* |
| IF | 2.74 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | JHOC-5(RCB1520) |