RRC ID 5478
Author García-Frigola C, Carreres MI, Vegar C, Mason C, Herrera E.
Title Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms.
Journal Development
Abstract Axons of retinal ganglion cells (RGCs) make a divergent choice at the optic chiasm to cross or avoid the midline in order to project to ipsilateral and contralateral targets, thereby establishing the binocular visual pathway. The zinc-finger transcription factor Zic2 and a member of the Eph family of receptor tyrosine kinases, EphB1, are both essential for proper development of the ipsilateral projection at the mammalian optic chiasm midline. Here, we demonstrate in mouse by functional experiments in vivo that Zic2 is not only required but is also sufficient to change the trajectory of RGC axons from crossed to uncrossed. In addition, our results reveal that this transcription factor regulates the expression of EphB1 in RGCs and also suggest the existence of an additional EphB1-independent pathway controlled by Zic2 that contributes to retinal axon divergence at the midline.
Volume 135(10)
Pages 1833-41
Published 2008-5-1
DOI 10.1242/dev.020693
PII dev.020693
PMID 18417618
MeSH Animals Axons / physiology* Female Green Fluorescent Proteins / metabolism Humans Mice Nuclear Proteins / biosynthesis Nuclear Proteins / genetics Nuclear Proteins / physiology* Optic Chiasm / cytology* Optic Chiasm / embryology Receptor, EphB1 / physiology* Retinal Ganglion Cells / cytology Retinal Ganglion Cells / metabolism Transcription Factors / biosynthesis Transcription Factors / genetics Transcription Factors / physiology*
IF 5.611
Times Cited 66
Mice RBRC00165