論文 - 詳細
| RRC ID | 54819 |
|---|---|
| 著者 | Gantumur E, Sakai S, Nakahata M, Taya M. |
| タイトル | Horseradish peroxidase-catalyzed hydrogelation consuming enzyme-produced hydrogen peroxide in the presence of reducing sugars. |
| ジャーナル | Soft Matter |
| Abstract |
In the present work, three kinds of reducing sugars: glucose, galactose, and mannose, are applied to horseradish peroxidase (HRP)-catalyzed hydrogelation of an aqueous solution containing natural polymers modified with phenolic hydroxyl moieties. In this system, HRP consumes hydrogen peroxide that was generated from the oxidation of thiol groups in HRP in the presence of reducing sugars. Herein, we highlight the versatility of applicable sugar types and the controllable hydrogel properties. The mechanical properties and microstructures of the resultant hydrogels can be well controlled by varying the concentration and the reducing power of sugars. Moreover, reducing sugar-independent cytocompatibility of the hydrogels was confirmed by the growth of cells on them. The wide selection of sugar types provides a better understanding of the reaction mechanism and enables the characterization of hydrogels with well-controlled properties. |
| 巻・号 | 15(10) |
| ページ | 2163-2169 |
| 公開日 | 2019-3-6 |
| DOI | 10.1039/c8sm01839a |
| PMID | 30672948 |
| MeSH | Biocatalysis* Horseradish Peroxidase / chemistry Horseradish Peroxidase / metabolism* Hydrogels / chemistry* Hydrogen Peroxide / chemistry* Hydrogen-Ion Concentration Models, Molecular Protein Conformation Reducing Agents / chemistry* Sugars / chemistry* |
| IF | 3.399 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 10T1/2(RCB0247) |