RRC ID 54845
Author Suzuki N, Niikura R, Ihara S, Hikiba Y, Kinoshita H, Higashishima N, Hayakawa Y, Yamada A, Hirata Y, Nakata R, Okamoto M, Sano M, Kushiyama A, Ichinose M, Woods SL, Worthley D, Iwamoto Y, Koike K.
Title Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.
Journal Cancer Prev Res (Phila)
Abstract doxazosin (alpha-blocker), but not febuxostat (xanthine oxidase inhibitor), suppressed the proliferation of human colorectal cancer cells. Doxazosin also decreased tumorigenesis in an AOM/DSS mouse colorectal cancer model. Alpha-blockers may prevent colorectal cancer.
Volume 12(3)
Pages 185-194
Published 2019-3
DOI 10.1158/1940-6207.CAPR-18-0288
PII 1940-6207.CAPR-18-0288
PMID 30700439
IF 4.021
Resource
Human and Animal Cells HCT116(RCB2979)