Reference - Detail
| RRC ID | 54845 |
|---|---|
| Author | Suzuki N, Niikura R, Ihara S, Hikiba Y, Kinoshita H, Higashishima N, Hayakawa Y, Yamada A, Hirata Y, Nakata R, Okamoto M, Sano M, Kushiyama A, Ichinose M, Woods SL, Worthley D, Iwamoto Y, Koike K. |
| Title | Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing. |
| Journal | Cancer Prev Res (Phila) |
| Abstract |
doxazosin (alpha-blocker), but not febuxostat (xanthine oxidase inhibitor), suppressed the proliferation of human colorectal cancer cells. Doxazosin also decreased tumorigenesis in an AOM/DSS mouse colorectal cancer model. Alpha-blockers may prevent colorectal cancer. |
| Volume | 12(3) |
| Pages | 185-194 |
| Published | 2019-3 |
| DOI | 10.1158/1940-6207.CAPR-18-0288 |
| PII | 1940-6207.CAPR-18-0288 |
| PMID | 30700439 |
| IF | 4.021 |
| Resource | |
| Human and Animal Cells | HCT116(RCB2979) |