論文 - 詳細
| RRC ID | 54853 |
|---|---|
| 著者 | Nakayama K, Seike M, Noro R, Takeuchi S, Matsuda K, Kunugi S, Kubota K, Gemma A. |
| タイトル | Tenascin XB Is a Novel Diagnostic Marker for Malignant Mesothelioma. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND/AIM:Malignant mesothelioma (MM) is an aggressive tumor with poor prognosis. The establishment of a new diagnostic and therapeutic approach for MM is expected. This study investigated the diagnostic significance of tenascin XB (TNXB) for MM. MATERIALS AND METHODS:TNXB gene expression was found to be significantly higher in MM tumor tissues compared to paired normal tissues, as assessed by the Gene Expression Omnibus database. The inhibition of TNXB using small interfering RNAs suppressed the proliferation and colony formation of MM cells. Expression of TNXB and calretinin, a current diagnostic marker of MM, was evaluated by immunohistochemistry. RESULTS:The sensitivity and specificity of TNXB for MM were 80.0% and 69.5%, respectively. When the detection of TNXB was combined with that of calretinin, 83.3% of MM cases were detected. CONCLUSION:These findings suggest that TNXB is a novel diagnostic biomarker for MM. A combination of detecting TNXB and calretinin may be useful for the differential diagnosis of MM from lung adenocarcinoma. |
| 巻・号 | 39(2) |
| ページ | 627-633 |
| 公開日 | 2019-2-1 |
| DOI | 10.21873/anticanres.13156 |
| PII | 39/2/627 |
| PMID | 30711938 |
| MeSH | Adenocarcinoma / diagnosis Adenocarcinoma / metabolism Biomarkers, Tumor / metabolism Calbindin 2 / metabolism Cell Line, Tumor Cell Proliferation Diagnosis, Differential Gene Expression Profiling Humans Immunohistochemistry Lung Neoplasms / diagnosis* Lung Neoplasms / metabolism* Mesothelioma / diagnosis* Mesothelioma / metabolism* Mesothelioma, Malignant RNA, Small Interfering / metabolism Sensitivity and Specificity Tenascin / metabolism* |
| IF | 1.935 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ACC-MESO-4(RCB2293) |