RRC ID 5486
著者 Wakisaka N, Inoue K, Ogonuki N, Miki H, Sekita Y, Hanaki K, Akatsuka A, Kaneko-Ishino T, Ishino F, Ogura A.
タイトル Ultrastructure of placental hyperplasia in mice: comparison of placental phenotypes with three different etiologies.
ジャーナル Placenta
Abstract Hyperplastic placentas have been reported in several experimental mouse models, including animals produced by somatic cell nuclear transfer, by inter(sub)species hybridization, and by somatic cytoplasm introduction to oocytes followed by intracytoplasmic sperm injection. Of great interest are the gross and histological features common to these placental phenotypes--despite their quite different etiologies--such as the enlargement of the spongiotrophoblast layers. To find morphological clues to the pathways leading to these similar placental phenotypes, we analyzed the ultrastructure of the three different types of hyperplastic placenta. Most cells affected were of trophoblast origin and their subcellular ultrastructural lesions were common to the three groups, e.g., a heavy accumulation of cytoplasmic vacuoles in the trophoblastic cells composing the labyrinthine wall and an increased volume of spongiotrophoblastic cells with extraordinarily dilatated rough endoplasmic reticulum. Although the numbers of trophoblastic glycogen cells were greatly increased, they maintained their normal ultrastructural morphology, including a heavy glycogen deposition throughout the cytoplasm. The fetal endothelium and small vessels were nearly intact. Our ultrastructural study suggests that these three types of placental hyperplasias, with different etiologies, may have common pathological pathways, which probably exclusively affect the development of certain cell types of the trophoblastic lineage during mouse placentation.
巻・号 29(8)
ページ 753-9
公開日 2008-8-1
DOI 10.1016/j.placenta.2008.05.008
PII S0143-4004(08)00173-2
PMID 18602690
MeSH Animals Female Hyperplasia Male Mice Mice, Inbred C57BL Microscopy, Electron Placenta / pathology* Placenta / ultrastructure* Placenta Diseases / etiology* Placenta Diseases / pathology Pregnancy
IF 3.177
引用数 10
WOS 分野 OBSTETRICS & GYNECOLOGY REPRODUCTIVE BIOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
実験動物マウス RBRC00657