論文 - 詳細
| RRC ID | 54895 |
|---|---|
| 著者 | Takagi Y, Kikuchi T, Niimura M, Ohno T. |
| タイトル | Anti-tumor effects of dendritic and tumor cell fusions are not dependent on expression of MHC class I and II by dendritic cells. |
| ジャーナル | Cancer Lett |
| Abstract |
Vaccination of fusion cells (FCs) made from dendritic and tumor cells elicits anti-tumor effects. We investigated whether major histocompatibility complex (MHC) class I and II play an important role in the induction of anti-tumor immunity by FCs. Immunization with fusion cells composed of syngeneic, allogeneic, or MHC I(-/-)II(-/-) DCs and B16 cells inhibited tumor growth. Elispot assay showed a higher population of interferon-gamma secreting T lymphocytes in mice immunized with fusion cells. These data suggest that anti-tumor effects of DCs and tumor cell fusions are not dependent on the expression of MHC class I and II on DCs. |
| 巻・号 | 213(1) |
| ページ | 49-55 |
| 公開日 | 2004-9-15 |
| DOI | 10.1016/j.canlet.2004.04.010 |
| PII | S0304383504003179 |
| PMID | 15312683 |
| MeSH | Animals Cancer Vaccines / immunology* Dendritic Cells / immunology* Female Genes, MHC Class I* Genes, MHC Class II* HLA Antigens / biosynthesis Immunotherapy / methods Melanoma / immunology* Melanoma / pathology Mice Mice, Inbred C57BL Mice, Knockout Neoplasms, Experimental Skin Neoplasms / immunology* Skin Neoplasms / pathology Tumor Cells, Cultured / immunology* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 |