| RRC ID |
54912
|
| Author |
Wang W, Zhang Y, Nakashima S, Nakamura S, Wang T, Yoshikawa M, Matsuda H.
|
| Title |
Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds.
|
| Journal |
J Nat Med
|
| Abstract |
The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition.
|
| Volume |
73(3)
|
| Pages |
439-449
|
| Published |
2019-6-1
|
| DOI |
10.1007/s11418-018-01276-2
|
| PII |
10.1007/s11418-018-01276-2
|
| PMID |
30847755
|
| PMC |
PMC7176596
|
| MeSH |
Animals
Cassia / chemistry*
Glycosides / pharmacology
Glycosides / therapeutic use*
Humans
Melanins / antagonists & inhibitors*
Mice
Seeds / chemistry*
|
| IF |
1.966
|
| Times Cited |
3
|
| Resource |
| Human and Animal Cells |
B16 melanoma 4A5(RCB0557) |
