論文 - 詳細
| RRC ID | 54912 |
|---|---|
| 著者 | Wang W, Zhang Y, Nakashima S, Nakamura S, Wang T, Yoshikawa M, Matsuda H. |
| タイトル | Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds. |
| ジャーナル | J Nat Med |
| Abstract |
The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition. |
| 巻・号 | 73(3) |
| ページ | 439-449 |
| 公開日 | 2019-6-1 |
| DOI | 10.1007/s11418-018-01276-2 |
| PII | 10.1007/s11418-018-01276-2 |
| PMID | 30847755 |
| PMC | PMC7176596 |
| MeSH | Animals Cassia / chemistry* Glycosides / pharmacology Glycosides / therapeutic use* Humans Melanins / antagonists & inhibitors* Mice Seeds / chemistry* |
| IF | 1.966 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |